- Reaction score
- 1,380
http://www.ncbi.nlm.nih.gov/m/pubmed/6249575/
Marihuana inhibits dihydrotestosterone binding to the androgen receptor.
AuthorsPurohit V,et al. Show allJournal
Endocrinology. 1980 Sep;107(3):848-50.
Affiliation
Abstract
Marihuana and its constitutents delta 9-tetrahydrocannabinol (delta 9-THC) and cannabinol (CBN) were tested for their ability to interact with the androgen receptor in rat prostate cytosol. Smoked marihuana condensate, delta 9-THC, and CBN inhibit specific binding of dihydrotestosterone (DHT) to the androgen receptor with a dissociatin constant of the inhibitors (Li) of 2.1-5.8 X 10(-7)M. in addition, other metabolites of delta 9-THC were also androgen antagonists. This data suggests that the anti-androgenic effects associated with marihuana use results, at least in part, from inhibition of androgen action at the receptor level.
Marihuana inhibits dihydrotestosterone binding to the androgen receptor.
AuthorsPurohit V,et al. Show allJournal
Endocrinology. 1980 Sep;107(3):848-50.
Affiliation
Abstract
Marihuana and its constitutents delta 9-tetrahydrocannabinol (delta 9-THC) and cannabinol (CBN) were tested for their ability to interact with the androgen receptor in rat prostate cytosol. Smoked marihuana condensate, delta 9-THC, and CBN inhibit specific binding of dihydrotestosterone (DHT) to the androgen receptor with a dissociatin constant of the inhibitors (Li) of 2.1-5.8 X 10(-7)M. in addition, other metabolites of delta 9-THC were also androgen antagonists. This data suggests that the anti-androgenic effects associated with marihuana use results, at least in part, from inhibition of androgen action at the receptor level.
