Why Is The Follicle Chemistry And Lifecycle And Interaction With The Rest Of The Body

[Xander94]

So f*****g difficult to study and decompose into a working solution for hair loss.

I want legit scientific answers I have no idea how or why baldness happens exactly

 

[Min0]

https://www.ncbi.nlm.nih.gov/pubmed/18844710

http://i67.tinypic.com/15fox76.png

Importantly, testosterone in vitro increases the ability of beard cells to promote increased growth of other beard dermal papilla cells and keratinocytes (112–114) but decreased that of androgenetic alopecia dermal papilla cells from both men (114) and stump-tailed macaques (117). This implies that an autocrine mechanism is involved; androgen-mediated changes do involve alterations in dermal papilla cell numbers as well as the amount of extracellular matrix (96). A need to modify the autocrine production of growth factors could contribute to the slow androgenic response that often takes many years to reach full effect (19)

it's about androgens not doing their real job (promoting genes that code for dermal papilla cell growth), instead they do the opposite on scalp hair of humans who have the wrong genes.

 

[cocona]

This one explains much of it:

Super simplified:
DHT -> Some missing inhibitor or activator -> PGD2

PGD2 -> Triggers an inflammatory reaction via GPR44 and premature telogen stages repeatedly over time -> Repeated follicle death causes the skin around the follicle to genetically mutate over time to overproduce PTGDS (A precursor to PGD2) resultin in skin that will continue to be PGD2 dominant even if 100% of DHT is inhibited.

It is an enormously complicated system that is only just now beginning to be understood. You want a complete answer of what is known so far it will take years of study to come close to that.