michael barry
Senior Member
- Reaction score
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Both of the getfitinib pictures we have seen with the hair growth were with cancer patients. Chemotherapy suppresses (and sometimes almost completely) the immune system. Both of these people likely had chemotherapy, and I thought that one of them had it for sure. Does it make more sense now?
Why do I have a feeling that the two drugs necessary for hair regrowth are going to turn out to be an immunosuppressant and getfitinib. These two drugs aren't approved for hair growth, just like Zohar said.
Just putting a immunosuppressant in a cream wont necessarily do the trick. Topical cyclosporin isn't as effective for androgenic alopecia as internal cyclosporin is. Internal cyclosporin usually has hirsutism as a side effect. Topical cyclosporin was tried for baldness if memory serves, but was only about 20% effective. The immune system is a "body-wide" phenomenon, with T-cells and Killer cells and marker cells going through the blood and lymphatics looking for "foreign" bodies to attack. So just blocking formation of these cells and whatnot in the scalp alone isn't going to keep others from "making their rounds".
For Cal and TAGOHL,
Neither of the two people whom we have seen getfitinib-related hairgrowth were on finasteride or minoxidil. Thats almost a given. But chances are good they had compromised immmuno-capacity from chemotherapy.
This is probably why nobody has had much success with the wounding/natural egf inhibitors or wouding/lithium thusfar other than them using carriers and whatnot that might interefere with the process anyway.
I keep going back to Experiment number 7 and the ENSUING experiments done with human skin grafted to SCID mice. They got hair EVERY TIME according to them. No EGF-Inhibition was needed......................the only difference between these mice acting as "life support" for the human skin grafted to their backs and us is that we have an immune system.
As for why animals can be wounded and regrow hair pretty regularily and we cannot-----pretty simple: Our immune systems are much more evovled than theirs. We all have read Hideo Uno's comparison between Stumptailed Macaque balding and human balding. The lymphocytic infiltrate, the collagenous streamers, the inflammation, the T-cell infiltration. The immune system gets involved in human androgenic (as well as areata) alopecia, but none of that is apparent in ape-balding. Their hair just shrinks. Our whole scalp changes.
I bet this is the "missing link" that would lead to success. The problem is.............................I cant think of anywhere one could get a hold of internal cyclo w/o a prescript. I'd like to be wrong about all of this............but what Zohar said not appears to really make sense. Those two drugs are indeed not for hair, but minoxidil or finas are. The anti-microbial and anti-biotic and anti-inflammatory now make sense also.
Why do I have a feeling that the two drugs necessary for hair regrowth are going to turn out to be an immunosuppressant and getfitinib. These two drugs aren't approved for hair growth, just like Zohar said.
Just putting a immunosuppressant in a cream wont necessarily do the trick. Topical cyclosporin isn't as effective for androgenic alopecia as internal cyclosporin is. Internal cyclosporin usually has hirsutism as a side effect. Topical cyclosporin was tried for baldness if memory serves, but was only about 20% effective. The immune system is a "body-wide" phenomenon, with T-cells and Killer cells and marker cells going through the blood and lymphatics looking for "foreign" bodies to attack. So just blocking formation of these cells and whatnot in the scalp alone isn't going to keep others from "making their rounds".
For Cal and TAGOHL,
Neither of the two people whom we have seen getfitinib-related hairgrowth were on finasteride or minoxidil. Thats almost a given. But chances are good they had compromised immmuno-capacity from chemotherapy.
This is probably why nobody has had much success with the wounding/natural egf inhibitors or wouding/lithium thusfar other than them using carriers and whatnot that might interefere with the process anyway.
I keep going back to Experiment number 7 and the ENSUING experiments done with human skin grafted to SCID mice. They got hair EVERY TIME according to them. No EGF-Inhibition was needed......................the only difference between these mice acting as "life support" for the human skin grafted to their backs and us is that we have an immune system.
As for why animals can be wounded and regrow hair pretty regularily and we cannot-----pretty simple: Our immune systems are much more evovled than theirs. We all have read Hideo Uno's comparison between Stumptailed Macaque balding and human balding. The lymphocytic infiltrate, the collagenous streamers, the inflammation, the T-cell infiltration. The immune system gets involved in human androgenic (as well as areata) alopecia, but none of that is apparent in ape-balding. Their hair just shrinks. Our whole scalp changes.
I bet this is the "missing link" that would lead to success. The problem is.............................I cant think of anywhere one could get a hold of internal cyclo w/o a prescript. I'd like to be wrong about all of this............but what Zohar said not appears to really make sense. Those two drugs are indeed not for hair, but minoxidil or finas are. The anti-microbial and anti-biotic and anti-inflammatory now make sense also.
unk: