Vb-1 Exerts Hair Growth-promoting Effects By Augmenting Wnt/β-catenin Signaling

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https://peerj.com/articles/4737/?utm_source=TrendMD&utm_campaign=PeerJ_TrendMD_1&utm_medium=TrendMD

-> VB-1 promotes the proliferation of human dermal papilla cells (hDPCs)

-> VB-1 activates Wnt/β-catenin signaling in hDPCs

->
VB-1 promotes hair shaft elongation in cultured human hair follicles

-> In the present study, we demonstrated that VB-1 increases the expression of human DP signature genes, such as lef1, wnt5a, and bmp2. Further studies are required to focus on whether VB-1 is suitable for long-term culture of hDPCs while maintaining their hair-inducing abilities.
Our results demonstrate that VB-1 decreases the expression of dkk1 in cultured hDPCs.

!! Interestingly, our data showed that VB-1 can promote the proliferation of hDPCs at a low dose; however, high dose of VB-1 inhibits the growth of these cells, which may be a result of the arrest of the cell cycle induced by high concentration of VB-1 as previously described in the cancer cells
 
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