tretinoin (vitamin a) article

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Hair Loss Study Abstract: Topical tretinoin for hair growth promotion.



Title
Topical tretinoin for hair growth promotion.
Author
Bazzano GS, Terezakis N, Galen W
Source
J Am Acad Dermatol, 15: 4 Pt 2, 1986 Oct, 880-3, 890-3
Abstract
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.
Language of Publication
English
Unique Identifier
87034471

 

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Appearantly retinoic acid has impact on gf3 and adenosine product bousts gf3 influence as well. According to post somewhere on site at least.
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Retinoic acid-regulated expression of fibroblast growth factor 3 requires the interaction between a novel transcription factor and GATA-4.

Murakami A, Thurlow J, Dickson C.

Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

fgf-3 shows a complex spatial-temporal pattern of transcription during mouse development, and the gene product appears to be an important intercellular signaling molecule. Here we show that the major enhancer, which is obligatory for transcription, is composed of three elements with different properties. Both functional analyses in undifferentiated and differentiated F9 cells and characterization of DNA-protein complexes in vitro have identified the sequence motifs GTGACT(C), ATTGT, and GATA as the key transcription factor binding sites. The GTGACT(C) motif, while not essential, is required for full enhancer activity. However, binding at ATTGT is crucial for transcriptional activity and is required for cooperative binding at the proximal GATA site. The GATA binding site mediates the retinoic acid/dibutyryl cyclic AMP stimulation of transcription and correlates with the binding of Gata-4 which is induced by retinoic acid in differentiating F9 cells. The ATTGT and GATA motifs are inactive when placed separately on a minimal thymidine kinase (TK) promoter, but together they act as a strong retinoic acid-regulated enhancer. In undifferentiated F9 cells, gata-4 expression stimulates the fgf-3 promoter, whereas in differentiated F9 cells already expressing gata-4, no further increase in promoter activity was observed.

PMID: 10358083 [PubMed - indexed for MEDLINE]

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[hairschmair]

minoxidil, copper peptides, Ketokonazole, lasers beams..

Is it just me or does just about EVERYTHING you put on your head seem to increase hair count by 32.787% compared to a placebo group??!??

I feel like someone's f*****g with us.

Excuse my language.

Jay

 

[Old Baldy]

:lol: :lol: :lol: