Topicals like RU and CB

[jd_uk]

Someone enlighten me. I understand the thinking behind them (less/no sides if topical), however surely there is always going to be some systemic effects? Like i heard of topicsl finasteride but we know that is absorbed through the skin hence why a woman shouldn't even handle the tablet.

Now, with these other topical AA's like RU and CB, aren't you essentially turning your own head into something which can't/shouldn't be touched by a woman? Surely it's not a good thing to leave AA hormones externally on your body where they are going to rub off on everything you touch? Bed sheets, people etc etc?

 

[Dench57]

5ARi's should not be handled by pregnant women because they may harm the foetus - DHT is absolutely fundamental to the normal growth of a male foetus. Having a 5ARi in a pregnant woman's bloodstream can cause birth defects. They're perfectly safe for women otherwise.

Also, anti-androgens (CB/RU) are not the same as 5ARi's and generally won't cause side effects unless a substantial amount is going systemic, getting into the bloodstream and blocking androgen receptors throughout body tissue (muscles, penis etc.) rather than local tissue (scalp). This is possible with RU, so you have to find the right dose for you.
Its highly unlikely with CB, since the active, anti-androgen molecule is rapidly metabolised by the skin to a harmless metabolite with no anti-androgen activity, preventing any systemic side effects - which is why it's considered "side-free".

 

[jd_uk]

5ARi's should not be handled by pregnant women because they may harm the foetus - DHT is absolutely fundamental to the normal growth of a male foetus. Having a 5ARi in a pregnant woman's bloodstream can cause birth defects. They're perfectly safe for women otherwise.

Also, anti-androgens (CB/RU) are not the same as 5ARi's and generally won't cause side effects unless a substantial amount is going systemic, getting into the bloodstream and blocking androgen receptors throughout body tissue (muscles, penis etc.) rather than local tissue (scalp). This is possible with RU, so you have to find the right dose for you.
Its highly unlikely with CB, since the active, anti-androgen molecule is rapidly metabolised by the skin to a harmless metabolite with no anti-androgen activity, preventing any systemic side effects - which is why it's considered "side-free".

How tested is this CB stuff both for safety and for effectiveness?

Can it really not cause systemic changes? E.g. lower testosterone etc? I mean this stuff is going to rub off on your pillow every night and build up...chances are some of that may get in your mouth too... just looking at the possibilities here..

Oh and cost, how much?

 

[abcdefg]

RU and CB are experimental treatments. Meaning they are not tested much if any so your pretty much rolling the dice here what could happen. RU and CB did have a few small studies, but nothing large and conclusive. CB has like a small human study with 3 month results that released pretty recently so that probably has more evidence than RU in humans.

 

[jd_uk]

RU and CB are experimental treatments. Meaning they are not tested much if any so your pretty much rolling the dice here what could happen. RU and CB did have a few small studies, but nothing large and conclusive. CB has like a small human study with 3 month results that released pretty recently so that probably has more evidence than RU in humans.

So really there's nothing solid on either sfety or effectiveness...yet people talk about it like its solid stuff.

5 years ago i remember people talking about it and still it doesn't seem to be any more confirmed than it was then..