Topical Resveratrol Liquid Solution

[tylerduren]

Ladies, gentlemen and inbetweeners...

Whos got experience with making fast drying liquid solutions and what are some nice vehicles ? ( not ferrari )

Im looking to dissolve :

Resveratrol

http://www.bulkpowders.co.uk/resveratrol-powder-99-trans-resveratrol.html

With some l-caritine

http://www.bulkpowders.co.uk/acetyl-l-carnitine.html

And a little caffeine.

I want a nice thin liquid that fast absorbs. What vehicle

Thanks

 

[stachu]

Ethanol. Cheap af

 

[tylerduren]

Is it safe to rub ethanol on head ?

This study compared RESV metabolites and their tissue distribution after oral uptake and skin absorption. Metabolomic analysis of various mouse tissues revealed that RESV can be absorbed and metabolized through skin. We detected sulfated and glucuronidated RESV metabolites, as well as dihydroresveratrol. These metabolites are thought to have lower pharmacological activity than RESV. Similar quantities of most RESV metabolites were observed 4 h after oral or skin administration, except that glucuronidated RESV metabolites were more abundant in skin after topical RESV application than after oral administration. This result is consistent with our finding of glucuronidated RESV metabolites in cultured skin cells. RESV applied to mouse ears significantly suppressed inflammation in the TPA inflammation model. The skin absorption route could be a complementary, potent way to achieve therapeutic effects with RESV.

Citation: Murakami I, Chaleckis R, Pluskal T, Ito K, Hori K, Ebe M, et al. (2014) Metabolism of Skin-Absorbed Resveratrol into Its Glucuronized Form in Mouse Skin. PLoS ONE 9(12): e115359. doi:10.1371/journal.pone.0115359

 

[tylerduren]

Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia.
Candelario-Jalil E1, de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL.
Author information

Abstract
BACKGROUND:
Neuroinflammatory responses are triggered by diverse ethiologies and can provide either beneficial or harmful results. Microglial cells are the major cell type involved in neuroinflammation, releasing several mediators, which contribute to the neuronal demise in several diseases including cerebral ischemia and neurodegenerative disorders. Attenuation of microglial activation has been shown to confer protection against different types of brain injury. Recent evidence suggests that resveratrol has anti-inflammatory and potent antioxidant properties. It has been also shown that resveratrol is a potent inhibitor of cyclooxygenase (COX)-1 activity. Previous findings have demonstrated that this compound is able to reduce neuronal injury in different models, both in vitro and in vivo. The aim of this study was to examine whether resveratrol is able to reduce prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2alpha (8-iso-PGF2 alpha) production by lipopolysaccharide (LPS)-activated primary rat microglia.

METHODS:
Primary microglial cell cultures were prepared from cerebral cortices of neonatal rats. Microglial cells were stimulated with 10 ng/ml of LPS in the presence or absence of different concentrations of resveratrol (1-50 microM). After 24 h incubation, culture media were collected to measure the production of PGE2 and 8-iso-PGF2 alpha using enzyme immunoassays. Protein levels of COX-1, COX-2 and microsomal prostaglandin E synthase-1 (mPGES-1) were studied by Western blotting after 24 h of incubation with LPS. Expression of mPGES-1 at the mRNA level was investigated using reverse transcription-polymerase chain reaction (RT-PCR) analysis.

RESULTS:
Our results indicate that resveratrol potently reduced LPS-induced PGE2 synthesis and the formation of 8-iso-PGF2 alpha, a measure of free radical production. Interestingly, resveratrol dose-dependently reduced the expression (mRNA and protein) of mPGES-1, which is a key enzyme responsible for the synthesis of PGE2 by activated microglia, whereas resveratrol did not affect the expression of COX-2. Resveratrol is therefore the first known inhibitor which specifically prevents mPGES-1 expression without affecting COX-2 levels. Another important observation of the present study is that other COX-1 selective inhibitors (SC-560 and Valeroyl Salicylate) potently reduced PGE2 and 8-iso-PGF2 alpha production by LPS-activated microglia.

CONCLUSION:
These findings suggest that the naturally occurring polyphenol resveratrol is able to reduce microglial activation, an effect that might help to explain its neuroprotective effects in several in vivo models of brain injury.

 

[tylerduren]

I will gunnie pig it in topical solution as i like the fact it has stopped my asthma

 

[Roberto_72]

Is it safe to rub ethanol on head ?

No offense but if you are asking this question then probably it is more safe if you do not experiment with new substances that may harm your hair.
Be safe.

 

[mr_robot]

What @Roborto_72 said, plus Resveratrol is a COX-1 (PGE1) inhibitor which is definitely not good.