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Patent Summary (US20160081901A1 – “Compositions and methods for hair growth”)
WO2020154304A1 (2020) explicitly claims losartan (and other ARBs like valsartan) applied directly to the scalp (as cream, oil, gel, or even injected) prevents/treats alopecia, including pattern baldness.
Direct relevance to Androgenetic Alopecia: Perifollicular fibrosis and TGF-β overexpression are key drivers of follicle miniaturisation in androgenetic alopecia — exactly the pathway topical losartan targets (same as in the patents).
Argument: ARBs act as local vasodilators → increase capillary blood supply and nutrient delivery to follicles; also promotes tissue repair.
WO2020154304A1 (2020) explicitly claims losartan (and other ARBs like valsartan) applied directly to the scalp (as cream, oil, gel, or even injected) prevents/treats alopecia, including pattern baldness.
Direct relevance to Androgenetic Alopecia: Perifollicular fibrosis and TGF-β overexpression are key drivers of follicle miniaturisation in androgenetic alopecia — exactly the pathway topical losartan targets (same as in the patents).
Argument: ARBs act as local vasodilators → increase capillary blood supply and nutrient delivery to follicles; also promotes tissue repair.