whatintheworld
Senior Member
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http://fuehairdoctor.co.uk/topical-dutasteride-dr-lupanzula/
"The idea behind topical dutasteride has to do with the chemical properties compared to finasteride. At the molecular level, dutasteride is more difficult to deliver as a topical agent to be absorbed through the skin due to the size of dutasteride molecules. They are larger than those of finasteride. This difficulty however becomes an advantage as the difficulty to get past the subcutaneous layer may prevent systemic absorption. The molecular size prevents deep penetration. In addition, dutasteride has a high lipophilicity of 4.94, compared to 3.03 of finasteride, which means it is less water soluble than finasteride or more “greasy”. This higher lipophilicity can in theory help dutasteride to remain in the skin longer as these properties tend to preclude the paracellular and follicular routes of ingress into the skin. "
"It is for these reasons that we have begun to offer topical dutasteride to our patients. We feel that the efficacy of topical dutasteride may be quite improved over that of topical finasteride and with a strong potential for having fewer side effects. Topical dutasteride is now available from Medikemos Hair Restoration in Brussels, Belgium, for all of our patients, past and future. "
Anyone want to give this a try? I am not sure how this was tested at all, if the risk of side effects is greater or smaller...
However, my hairline is not holding up on finasteride, so I'm looking into alternative options. But Dutasteride just scares the hell out of me.
"The idea behind topical dutasteride has to do with the chemical properties compared to finasteride. At the molecular level, dutasteride is more difficult to deliver as a topical agent to be absorbed through the skin due to the size of dutasteride molecules. They are larger than those of finasteride. This difficulty however becomes an advantage as the difficulty to get past the subcutaneous layer may prevent systemic absorption. The molecular size prevents deep penetration. In addition, dutasteride has a high lipophilicity of 4.94, compared to 3.03 of finasteride, which means it is less water soluble than finasteride or more “greasy”. This higher lipophilicity can in theory help dutasteride to remain in the skin longer as these properties tend to preclude the paracellular and follicular routes of ingress into the skin. "
"It is for these reasons that we have begun to offer topical dutasteride to our patients. We feel that the efficacy of topical dutasteride may be quite improved over that of topical finasteride and with a strong potential for having fewer side effects. Topical dutasteride is now available from Medikemos Hair Restoration in Brussels, Belgium, for all of our patients, past and future. "
Anyone want to give this a try? I am not sure how this was tested at all, if the risk of side effects is greater or smaller...
However, my hairline is not holding up on finasteride, so I'm looking into alternative options. But Dutasteride just scares the hell out of me.
