To College

[blaze]

heh college,

Where did you get the info that grapefruit juice makes more dutasteride get absorbed?

And what sort of grapefruit juice do you take dutasteride with? Freshly squeezed or processed store bought stuff?

 

[CCS]

it is stated in many pharmaceutical sites, and is well known info.

I eat a grape fruit, and chew well and drink water with my dutasteride.

 

[RSG]

Doctors believe the 'furanocoumarin' chemical found in grapefruit juice binds to enzyme in your intestinal tract known as 'CYP3AA'. When grapefruit juice binds to the enzyme, its easier for the medication to pass from your gut to your bloodstream. Medication levels in blood will be higher than normal as a result.

 

[CCS]

it also inhibits p450 in the liver, which breaks down dutasteride. I think that will cause an even greater increase. The amount is unknown, though it could be 5x. I would not mind that. I just don't want it to reach 100x or something like that. I thought I read that p450 is in the intestine too, and actually metabolises some of it as it enters, but i guess it would not have enough time to do much of that.

I know I'm taking a risk. I know some other drugs that are normally only absorbed 20% jump to 80+5 absorption in the intestine. I hope it does not completely shut down p450, or my levels will continue to climb without bounds. scary thought. But most drugs don't completely shut down any enzymes at a low level. the grapefruit effects are worn off after about 48 hours.

I think if I inhibit the enzyme by 80%, that would give my 0.5mg/day the effect of 2.5mg/day, plus the extra entering the intestine. And when that builds up, it would take a long time to go away.

I need to find out what concentration can cause birthdefects from sperm entering women. 0.5mg per day does not, if I remember correctly, but I'm not sure about 2.5mg/day.

jayman, you out there? do you remember those studies you and I posted?