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The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone.
Authors:
Li JJ; Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
Li Z; Intelligent Synthetic Biology Center, KAIST, Daejeon, 34141, Republic of Korea.
Gu LJ; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea.
Choi KJ; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea.
Kim DS; KM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
Kim HK; Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea. hkkim@kiom.re.kr.
Sung CK; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea. kchsung@cnu.ac.kr.
Source:
Journal Of Natural Medicines [J Nat Med] 2017 Sep 13. Date of Electronic Publication: 2017 Sep 13.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Springer Country of Publication: Japan NLM ID: 101518405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0293 (Electronic) Linking ISSN: 13403443 NLM ISO Abbreviation: J Nat Med
Imprint Name(s):
Original Publication: Tokyo : Springer
Abstract:
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential. BFPE also showed in vivo anti-androgenic activity following the use of a hair growth assay in testosterone-sensitive male C57Bl/6NCrSlc mice. Furthermore, the effects of cell viability promotion were investigated following an in vitro analysis in primary hair follicle fibroblast cells (PHFCs) treated with RA. The results suggested that RA was the active compound in P. frutescens that triggers hair growth, and RA could be a potential therapeutic agent for the promotion of hair growth and prevention of androgenetic alopecia (Androgenetic Alopecia).
Entry Date(s):
Date Created: 20170914 Latest Revision: 20170914
Update Code:
20170914
DOI: 10.1007/s11418-017-1116-3
Perilla frutescens at Wikipedia
Authors:
Li JJ; Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
Li Z; Intelligent Synthetic Biology Center, KAIST, Daejeon, 34141, Republic of Korea.
Gu LJ; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea.
Choi KJ; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea.
Kim DS; KM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
Kim HK; Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea. hkkim@kiom.re.kr.
Sung CK; Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, 220 Gung-dong, Yusung-gu, Daejeon, 34134, Republic of Korea. kchsung@cnu.ac.kr.
Source:
Journal Of Natural Medicines [J Nat Med] 2017 Sep 13. Date of Electronic Publication: 2017 Sep 13.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Springer Country of Publication: Japan NLM ID: 101518405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0293 (Electronic) Linking ISSN: 13403443 NLM ISO Abbreviation: J Nat Med
Imprint Name(s):
Original Publication: Tokyo : Springer
Abstract:
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential. BFPE also showed in vivo anti-androgenic activity following the use of a hair growth assay in testosterone-sensitive male C57Bl/6NCrSlc mice. Furthermore, the effects of cell viability promotion were investigated following an in vitro analysis in primary hair follicle fibroblast cells (PHFCs) treated with RA. The results suggested that RA was the active compound in P. frutescens that triggers hair growth, and RA could be a potential therapeutic agent for the promotion of hair growth and prevention of androgenetic alopecia (Androgenetic Alopecia).
Entry Date(s):
Date Created: 20170914 Latest Revision: 20170914
Update Code:
20170914
DOI: 10.1007/s11418-017-1116-3
Perilla frutescens at Wikipedia
