kirk
Established Member
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I was researching on ketoconazole's anti fungal properties, and I came across this study. I remembered that Nitric Oxide is trending in this section so I decided to post it. What I gather from this is that NO has anti fungal, bacterial, microbial etc.. properties. There is also mention of methods of getting NO into cells. ex: Zeolites
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442839/#__abstractid963347title
[h=2]Abstract[/h]Nitric oxide (NO) is a short-lived, diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442839/#__abstractid963347title
[h=2]Abstract[/h]Nitric oxide (NO) is a short-lived, diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.
