The efficacy of 3% minoxidil vs. combined 3% minoxidil and Korean red ginseng
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The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin.
AuthorsShin HS, et al. Show all Journal
Eur J Pharmacol. 2014 Mar 12. pii: S0014-2999(14)00153-8. doi: 10.1016/j.ejphar.2014.02.024. [Epub ahead of print]
Affiliation
Abstract
This study was conducted to confirm the possibility of using minor ginseng saponin F2 by oral administration on hair anagen induction effects. The signaling pathway and anagen induction effect of ginsenoside F2 were investigated and compared with finasteride on the effect of hair growth induction. The cell-based MTT assay results indicated that the proliferation rates of HHDPC and HaCaT treated with F2 significantly increased by 30% compared with the finasteride-treated group. A western blot study showed that the expression of β-catenin Lef-1 and DKK-1 increased by 140, 200% and decreased by 40% in the F2-treated group, respectively compared to that of finasteride-treated group. C57BL/6 mice were subjected to the same treatments. The hair growth promotion rates were compared with groups treated with finasteride, which was 20% higher in the F2-treated group. Tissue histological analysis results showed the number of hair follicles, thickness of the epidermis, and follicles of the anagen phase which increased in the F2-treated group, compared with the finasteride-treated groups. Moreover, the effect of F2 on hair growth was confirmed through the immunofluorescence (IF) methods indicating the expression aspect of Wnt signal pathway-related factors in the tissue of C57BL/6 mouse. Our results considered the expression increase in β-catenin, Lef-1 which was suggested as a major factor related to the development and growth of hair follicle and the decrease in DKK-1 when entering catagen by F2. As the data showed, F2 might be a potential new therapeutic source for anagen induction and hair growth through the Wnt signal pathway.
Copyright © 2014 Elsevier B.V. All rights reserved.
AuthorsShin HS, et al. Show all Journal
Eur J Pharmacol. 2014 Mar 12. pii: S0014-2999(14)00153-8. doi: 10.1016/j.ejphar.2014.02.024. [Epub ahead of print]
Affiliation
Abstract
This study was conducted to confirm the possibility of using minor ginseng saponin F2 by oral administration on hair anagen induction effects. The signaling pathway and anagen induction effect of ginsenoside F2 were investigated and compared with finasteride on the effect of hair growth induction. The cell-based MTT assay results indicated that the proliferation rates of HHDPC and HaCaT treated with F2 significantly increased by 30% compared with the finasteride-treated group. A western blot study showed that the expression of β-catenin Lef-1 and DKK-1 increased by 140, 200% and decreased by 40% in the F2-treated group, respectively compared to that of finasteride-treated group. C57BL/6 mice were subjected to the same treatments. The hair growth promotion rates were compared with groups treated with finasteride, which was 20% higher in the F2-treated group. Tissue histological analysis results showed the number of hair follicles, thickness of the epidermis, and follicles of the anagen phase which increased in the F2-treated group, compared with the finasteride-treated groups. Moreover, the effect of F2 on hair growth was confirmed through the immunofluorescence (IF) methods indicating the expression aspect of Wnt signal pathway-related factors in the tissue of C57BL/6 mouse. Our results considered the expression increase in β-catenin, Lef-1 which was suggested as a major factor related to the development and growth of hair follicle and the decrease in DKK-1 when entering catagen by F2. As the data showed, F2 might be a potential new therapeutic source for anagen induction and hair growth through the Wnt signal pathway.
Copyright © 2014 Elsevier B.V. All rights reserved.
ryan82
Established Member
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- 18
do you have now more sexual desire with ginseng? and were did you buy it?
I.D WALKER
Senior Member
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- 869
I'm pretty sure you can read the writing on the wall in BOLD font on this item. Any company that advertises it's product as 'miraculous' is simply telling all their prospective patrons to abandon all faculties of reason. On the other hand, give it a try and if it achieves half the benefits it boasts then I'm sold.
nfire: All the best.
nfire: All the best.