The 500 dalton rule....

[Jacob]

...is outdated. I've posted other things on this in the past(as well as the transfollicular route). Just came across this:

http://www.jrxbiotech.com/dermx.html

Delivering small and large molecules ("macro-molecules") up to 460,000 Daltons in size

Large Molecules: Traditional delivery system technologies can deliver only small molecules to the skin, thus severely limiting their efficacy and dosage range and flexibility. The DermX[SUP]TM[/SUP] MegasphereTM System, however, can deliver both small molecules (like extracts) and large molecules (like proteins). DermX[SUP]TM[/SUP] MegasphereTM's unique value is its ability to deliver compounds that are potentially 10,000 times larger than those found in other non-invasive, passive systems.

http://www.transdermalcorp.com/technology

http://www.transdermalcorp.com/clinical-studies

The novel delivery system is capable of delivering proteins, peptides, hormones, vaccines or small molecule drugs. The molecular weight of the macromolecular pharmaceutical agent can range between about 1,000 and 2,000,000 daltons.

• The thearpeutic agent is presented in a mixed micellar form, with a micelle size of approximately one to 10 nanometers (nm) or higher. Nano particles are made from combinations of micelles (surfactants and protein solubilizers), coated with lipid molecules
• Nano paticles size; less than 1-10 nano meters smaller than the skin pores
• Nano Particles Physically entraps active without any changes in the chemical composition
• Stabilizes the actives: shelf stable at room temperature for extended period of time without refrigeration)

- - - Updated - - -

http://www.convoytx.com/page/platform-technology

has demonstrated delivery of small molecules and large molecules up to 1,000,000 daltons

 

[Jacob]

Remember ASTRESSIN-B..the talk about it being "too big"? Not with the right encapsulation. Whether it works or not :dunno:

BTW..Hairscience...your mailbox is full again. I wish this forum had that "alert" that told you to clean out your mailbox in order to receive new messages.

 

[squeegee]

Transdermal SOD?

 

[Jacob]

Absolutely unk:

Hairscience was one of those talking about this issue...wonder if he believes me yet :woot: