HELP!! I am a 27yr old female suffering from HAIRLOSS. I have seen countless doctors and none of them give me hope. My family all has thick hair including my 65yr old parents. I have been to every specialist and they all give me minoxidil and spironolactone, however neither has helped the regrowth. Below is my most recent biopsy which was VERY painful and my doctors response was "ready for a hair transplant!" Again I am 27 and female and I am desperately seeking help. I am unable to interpret the below and was hoping someone could help. I would give anything to have my hair back to the way it was 5 yrs ago. Thoughts? Advice? Help?!?
Desperately seeking Answers!
T.Leela
____________________
Clinical information
1. 2mm punch. Mid inf. Scalp frontal submitted for DIF, B. 4mm punch mid frontal superior scalp: A, B:/Female pattern hair loss, autoimmune hairloss. 704.00. IDX mc
Diagnoses:
A. skin, mid inferior scalp frontal, submitted for5 DIF:Ã¥
- Positive lupus band test of IgM isotype
Comment (specimen a):
There is a fairly striking deposition of IgM along the dermal-epidermal junction and as well there is staining within the epithelium for IgA, IgM and IgG essentially defining a very immunoreactant profile. This profile is not dissimilar to other cases of androgenetic alopecia
2. Skin, mid frontal superior scalp:
–Non-scarring alopecia consistent with androgenetic alopecia
Comment (specimen b):
The findings are those of a fairly advances state of non-scarring alopecia. I would tend to favor a diagnosis of androgenetic alopecia. There is one terminal hair unit however that suggests the possibility of alopecia areata although I do not see frank lymphocyctic bulbitis. I am curious to know if in fact this patent has and clinical features of alopecia areata. If indeed the clinical presentation is more in keeping with common baldness I would interpret the process as an inflammatory immunogenic variant of androgenetic alopecia, especially given the very impressive immunoflurescent profile. We will destain slide B1 (D4-6) to see if we can actually identify any lymphocytes permeating the bulbar epithelium
Microscopic description
Direct immunofluorescent studies have been performed on specimen A, the results of which are as follows:
IgG: There is +1-2/3 fine granular staining of epidermal keratinocytes within the epidermis and hair follicle
IgA: There is a fairly intense granular staining in the sebocytes and other root sheath of a hair follicle as well as +1-2/3 fine granular staining of epidermal keratinocytes
IgM: There is a continuous band of +3/3 granular staining along the dermal-epidermal junction as well as +3/3 granular staining within the basement membrane zone of the hair follicle
C3: significant immunoreactivity is not identified
C3d: there is an interrupted band of +1-2/3 fine granular staining along the dermal-epidermal junction and within the follicular basement membrane zone
C4d: negative
There is an average normal number of anagen hair follicles however they appear shorter and thinner. There is a superficial and mild perivascular and slightly perifolliclar infiltrate predominantly of lymphocytes. PAS stain fails to reveal fungal hyphae or a thickened basement membrane. There are yeasts of Pityrosporum on the epidermal surface
?
Desperately seeking Answers!
T.Leela
____________________
Clinical information
1. 2mm punch. Mid inf. Scalp frontal submitted for DIF, B. 4mm punch mid frontal superior scalp: A, B:/Female pattern hair loss, autoimmune hairloss. 704.00. IDX mc
Diagnoses:
A. skin, mid inferior scalp frontal, submitted for5 DIF:Ã¥
- Positive lupus band test of IgM isotype
Comment (specimen a):
There is a fairly striking deposition of IgM along the dermal-epidermal junction and as well there is staining within the epithelium for IgA, IgM and IgG essentially defining a very immunoreactant profile. This profile is not dissimilar to other cases of androgenetic alopecia
2. Skin, mid frontal superior scalp:
–Non-scarring alopecia consistent with androgenetic alopecia
Comment (specimen b):
The findings are those of a fairly advances state of non-scarring alopecia. I would tend to favor a diagnosis of androgenetic alopecia. There is one terminal hair unit however that suggests the possibility of alopecia areata although I do not see frank lymphocyctic bulbitis. I am curious to know if in fact this patent has and clinical features of alopecia areata. If indeed the clinical presentation is more in keeping with common baldness I would interpret the process as an inflammatory immunogenic variant of androgenetic alopecia, especially given the very impressive immunoflurescent profile. We will destain slide B1 (D4-6) to see if we can actually identify any lymphocytes permeating the bulbar epithelium
Microscopic description
Direct immunofluorescent studies have been performed on specimen A, the results of which are as follows:
IgG: There is +1-2/3 fine granular staining of epidermal keratinocytes within the epidermis and hair follicle
IgA: There is a fairly intense granular staining in the sebocytes and other root sheath of a hair follicle as well as +1-2/3 fine granular staining of epidermal keratinocytes
IgM: There is a continuous band of +3/3 granular staining along the dermal-epidermal junction as well as +3/3 granular staining within the basement membrane zone of the hair follicle
C3: significant immunoreactivity is not identified
C3d: there is an interrupted band of +1-2/3 fine granular staining along the dermal-epidermal junction and within the follicular basement membrane zone
C4d: negative
There is an average normal number of anagen hair follicles however they appear shorter and thinner. There is a superficial and mild perivascular and slightly perifolliclar infiltrate predominantly of lymphocytes. PAS stain fails to reveal fungal hyphae or a thickened basement membrane. There are yeasts of Pityrosporum on the epidermal surface
?
