autonmousone1980
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upon reading how minoxidil works by activating an atp sensitive potassium channel, i made the deduction that i may be deficient in magnesium, as atp cannot be made without magnesium, and if atp production were reduced for some reason, that could indicate a lack of MG. Also magnesium is necessary for the relaxation of the muscles including during times of stress, or after bouts of stress. if you were to go through a time period in your life where your MG requirement exceded its supply, over time that would lead to a deficiency. Its all about the metabolic demands that you body has gone through and if your diet was sufficient.
For MG, 1% is stored in the blood, 70% in bones and about 30% in the cells. I thought that what may be happening was my body was trying to function on low reserves, so if i restore the reserve to somewhere near full, all other processes requiring atp will, hopefully, resume.
atp is the most general form of intercellular energy, which all cells need to reproduce them selves, and supposedly magnesium is somehow very important for protein synthesis, perhaps through the atp dependant pathways.
based on this hypothesis i purchased the most absorbable form of magnesium, mag citrate in a powder that is mixed with water. The brand was natural calm and i felt an immense change in my body within 45 minutes, and i new immediatly that at least in my situation, it was at least a piece of the hairloss pie.
here is the study for minoxidil.
FASEB J. 2008 Jun;22(6):1725-36. Epub 2008 Feb 7. Links
Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil.Shorter K, Farjo NP, Picksley SM, Randall VA.
Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK.
Hair disorders cause psychological distress but are generally poorly controlled; more effective treatments are required. Despite the long-standing use of minoxidil for balding, its mechanism is unclear; suggestions include action on vasculature or follicle cells. Similar drugs also stimulate hair, implicating ATP-sensitive potassium (K(ATP)) channels. To investigate whether K(ATP) channels are present in human follicles, we used organ culture, molecular biological, and immunohistological approaches. Minoxidil and tolbutamide, a K(ATP) channel blocker, opposed each other's effects on the growing phase (anagen) of scalp follicles cultured in media with and without insulin. Reverse transcriptase-polymerase chain reaction identified K(ATP) channel component gene expression including regulatory sulfonylurea receptors (SUR) SUR1 and SUR2B but not SUR2A and pore-forming subunits (Kir) Kir6.1 and Kir6.2. When hair bulb tissues were examined separately, epithelial matrix expressed SUR1 and Kir6.2, whereas both dermal papilla and sheath exhibited SUR2B and Kir6.1. Immunohistochemistry demonstrated similar protein distributions. Thus, human follicles respond biologically to K(ATP) channel regulators in culture and express genes and proteins for two K(ATP) channels, Kir6.2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels. These findings indicate that human follicular dermal papillae contain K(ATP) channels that can respond to minoxidil and that tolbutamide may suppress hair growth clinically; novel drugs designed specifically for these channels could treat hair disorders.
sound solid??? for me my fatigue is almost non existent since starting magnesium and heart beat and resistance to stress is much better in the last 6 days, so thats a great sign, i hope to experiance more improvements in the coming weeks, im also sleeping better as low mag means high calcium which cells get saturated with calcium and dont function as well, the pineal gland is prone to calcification, so my sleep has been super great which may also mean my cells are balancing out with more magnesium and expelling calcium, as cells compete for calcium and magnesium to maintain some balance.
For MG, 1% is stored in the blood, 70% in bones and about 30% in the cells. I thought that what may be happening was my body was trying to function on low reserves, so if i restore the reserve to somewhere near full, all other processes requiring atp will, hopefully, resume.
atp is the most general form of intercellular energy, which all cells need to reproduce them selves, and supposedly magnesium is somehow very important for protein synthesis, perhaps through the atp dependant pathways.
based on this hypothesis i purchased the most absorbable form of magnesium, mag citrate in a powder that is mixed with water. The brand was natural calm and i felt an immense change in my body within 45 minutes, and i new immediatly that at least in my situation, it was at least a piece of the hairloss pie.
here is the study for minoxidil.
FASEB J. 2008 Jun;22(6):1725-36. Epub 2008 Feb 7. Links
Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil.Shorter K, Farjo NP, Picksley SM, Randall VA.
Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK.
Hair disorders cause psychological distress but are generally poorly controlled; more effective treatments are required. Despite the long-standing use of minoxidil for balding, its mechanism is unclear; suggestions include action on vasculature or follicle cells. Similar drugs also stimulate hair, implicating ATP-sensitive potassium (K(ATP)) channels. To investigate whether K(ATP) channels are present in human follicles, we used organ culture, molecular biological, and immunohistological approaches. Minoxidil and tolbutamide, a K(ATP) channel blocker, opposed each other's effects on the growing phase (anagen) of scalp follicles cultured in media with and without insulin. Reverse transcriptase-polymerase chain reaction identified K(ATP) channel component gene expression including regulatory sulfonylurea receptors (SUR) SUR1 and SUR2B but not SUR2A and pore-forming subunits (Kir) Kir6.1 and Kir6.2. When hair bulb tissues were examined separately, epithelial matrix expressed SUR1 and Kir6.2, whereas both dermal papilla and sheath exhibited SUR2B and Kir6.1. Immunohistochemistry demonstrated similar protein distributions. Thus, human follicles respond biologically to K(ATP) channel regulators in culture and express genes and proteins for two K(ATP) channels, Kir6.2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels. These findings indicate that human follicular dermal papillae contain K(ATP) channels that can respond to minoxidil and that tolbutamide may suppress hair growth clinically; novel drugs designed specifically for these channels could treat hair disorders.
sound solid??? for me my fatigue is almost non existent since starting magnesium and heart beat and resistance to stress is much better in the last 6 days, so thats a great sign, i hope to experiance more improvements in the coming weeks, im also sleeping better as low mag means high calcium which cells get saturated with calcium and dont function as well, the pineal gland is prone to calcification, so my sleep has been super great which may also mean my cells are balancing out with more magnesium and expelling calcium, as cells compete for calcium and magnesium to maintain some balance.