Scientifically speaking, why doesn't finasteride work immediatly?

[Guest]

....or a better question, what is the reason finasteride works at different times for different people (some see results at 3-4 months, some see at 15-16 months)?

My theory (I'm no expert, please correct any mistakes):

Since Finasteride is only responsible for stopping the conversion of DHT from Testosterone, there is still lots of DHT in the body (after the first dose) that can only be released by binding to a hair follicle and then shedding. So the only way that finasteride can "work" is if all excess DHT is released from each infected hair follicle via the androgen receptors on a hair follicle which finasteride is incapable of doing (assuming DHT is the main culprit).

Do you see the problem here?

The reason finasteride doesn't work for some is that they couldn't get rid of all DHT infected hairs before the little DHT that is still converted after finasteride use has time to build up again. So the drug did wonders for the conversion of DHT, but it did nothing for the DHT that was floating around inside you before you stoped its conversion from Testosterone.

Along with this theory, the later you notice results from finasteride the less results you have from the drug.

I'm going on 10 months on June 2nd with inconclusive results...

 

[Fallout Boy]

Im same situation as you... im starting montoh 9 tomorrow with no results.

no maintenance.

 

[dead]

Finasteride works immediately (well within the first 24 hours)

The results of the lowering of dihyrotetosterone may take months to show themselves.

 

[iamnaked]

The dht or the receptors themselves must somehow degrade... But one way of looking at it is that hairloss is not immediate - your hair takes time to get worse, so it must take at least that time to get better. I would say a rule of thumb would be to expect no greater result in a year than the amount of ground you can lose in a year.

 

[chewbaca]

Re: Scientifically speaking, why doesn't finasteride work immediatly

....or a better question, what is the reason finasteride works at different times for different people (some see results at 3-4 months, some see at 15-16 months)?

My theory (I'm no expert, please correct any mistakes):

Since Finasteride is only responsible for stopping the conversion of DHT from Testosterone, there is still lots of DHT in the body (after the first dose) that can only be released by binding to a hair follicle and then shedding. So the only way that finasteride can "work" is if all excess DHT is released from each infected hair follicle via the androgen receptors on a hair follicle which finasteride is incapable of doing (assuming DHT is the main culprit).

Do you see the problem here?

The reason finasteride doesn't work for some is that they couldn't get rid of all DHT infected hairs before the little DHT that is still converted after finasteride use has time to build up again. So the drug did wonders for the conversion of DHT, but it did nothing for the DHT that was floating around inside you before you stoped its conversion from Testosterone.

Along with this theory, the later you notice results from finasteride the less results you have from the drug.

I'm going on 10 months on June 2nd with inconclusive results...

Just a couple of Questions


1) how long does the body retain the accumulated finasteride before and after ( 30%) staring propecia?

2)IS this the reason , the accumulated 20-30% after 5 years which make finasteride stop working for some?

3) in that case it better to start on dutasteride first for a year than later switch to finasteride for maintenance?
Since dutasteride reduces 90%

 

[Guest]

EXACTLY Chewbaca.

I am not just asking a question here, I'm trying to get people to build theorys from the answers we do know.

If my built theory holds any relevence, than Finasteride is only good for people who don't have shitloads of DHT already in the body. Left over DHT (after the first finasteride dose) could take years to finally make its way to the androgen receptor and then longer for the hair follicle to shed as many times as it takes to excrete ALL DHT on that hair follicle.

Do you guys see where I'm going with this thread (Tynan and Iamnaked do not)?

Further more (based entirely off of my theory, assuming DHT is the main culprit in male pattern baldness) Anti Andogens (spironolactone) would only slow this excretion of DHT because it needed that androgen receptor to be free. Without these receptors, how is the excess DHT supposed to exit the body.

Is it worse to combine an anti androgen with Finasteride?

This would explain why Minoxidil and finasteride are synergistic. The Min works faster at releasing the DHT infested hair follicle because of the shedding that occurs, assuming the DHT was stopped by the finasteride intake.

So to conclude this theory, to make the finasteride work faster, how could you shed (or get rid of) all DHT infested hairs *BEFORE* the first dose of Finasteride.

 

[Guest]

Fallout Boy, I have *inconclusive* results, not *no* results (see the difference).

I know for a fact that the finasteride I take is stopping the conversion of DHT from Testosterone. I still after ten months must have DHT still in me waiting to be released because I haven't seen improvement in hair growth.

Actually, my hair seems to get a little better, but then worse. I feel I am blocking just enough DHT to see improvent, but there is still enough DHT in me added to the DHT that is still being converted to put my hairs improvement (or maintainence) on hold.

 

[hair23]

As far as I know, when the hair sheds, the follicle is still in the scalp, and the DHT is still attaced to the receptor. I wonder how we can rid the follicules of already-attached DHT. Does spironolactone or other anti-androgens to the trick? Or does spironolactone only attack free-floating DHT in the scalp as opposed to DHT that has already joined the follicle at the appropriate recetpor?

EXACTLY Chewbaca.

This would explain why Minoxidil and finasteride are synergistic. The Min works faster at releasing the DHT infested hair follicle because of the shedding that occurs, assuming the DHT was stopped by the finasteride intake.

So to conclude this theory, to make the finasteride work faster, how could you shed (or get rid of) all DHT infested hairs *BEFORE* the first dose of Finasteride.

 

[Bryan]

If my built theory holds any relevence, than Finasteride is only good for people who don't have shitloads of DHT already in the body. Left over DHT (after the first finasteride dose) could take years to finally make its way to the androgen receptor and then longer for the hair follicle to shed as many times as it takes to excrete ALL DHT on that hair follicle.

That's the strangest theory I've heard yet! It bears no similarity whatsoever to real-life physiology...

Do you guys see where I'm going with this thread (Tynan and Iamnaked do not)?

Add my name to that list.

Further more (based entirely off of my theory, assuming DHT is the main culprit in male pattern baldness) Anti Andogens (spironolactone) would only slow this excretion of DHT because it needed that androgen receptor to be free.

DHT molecules that don't bind with androgen receptors will either diffuse out of the cell and into the bloodstream, or perhaps get directly metabolized by enzymes within the cell to weaker products and then eventually excreted.

Without these receptors, how is the excess DHT supposed to exit the body.

Diffuses out of the cell and into the bloodstream, and then excreted from the body. DHT has a surprisingly short half-life in the bloodstream of only a couple hours or so...

So to conclude this theory...

PLEASE conclude this theory!

Bryan

 

[Guest]

Thanks Bryan, What you said is exactly what I wanted to hear. Now this is starting to make more sense. I had this idea and I was hoping people would correct me, no reason to be a smart *** about it, I just didn't know.

Like I said, I'm no expert.

Thanks guys for your postings.

 

[Bryan]

Sorry, PL, I guess I was in a feisty mood when I wrote that. I try to limit myself to one smart-*** answer per month, and that was the one for May!

Bryan