Scientists develop a new gene-editing tool that could help treat many disorders caused by gene mutations
Researchers have developed a new tool -- dubbed SATI -- to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology could be expanded for use in a broad range of gene mutation conditions such as Huntington's disease and the rare premature aging syndrome, progeria.
The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.
Now, Salk Institute researchers have developed a new tool -- dubbed SATI -- to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology, described in Cell Research on August 23, 2019, could be expanded for use in a broad range of gene mutation conditions such as Huntington's disease and the rare premature aging syndrome, progeria.
https://www.sciencedaily.com/releases/2019/08/190823182700.htm
Existing genome-editing approaches, unfortunately, often cause damage. The Salk Institute team says they have created a safer approach.
The new genome-editing technology, recently described in a Cell Research paper, could be used to treat a wide range of gene mutation conditions such as Huntington’s disease and progeria.
The tool, dubbed SATI (Single homology Arm donor mediated intro-Targeting Integration), builds on HITI, a variant of the already established CRISPR-Cas9 gene-editing technique.
As Engadget reports, CRISPR-Cas9 treats mutations by inserting a healthy copy of a problematic gene into the non-coding region of DNA.
SATI, the team says, can perform edits on genes while the mutation is at work. While the DNA is repairing itself, the normal gene becomes integrated into the genome alongside the old one - this eliminates the troublesome gene without the risk of older procedures.
“This study has shown that SATI is a powerful tool for genome editing,” Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper, said in a press release.
https://interestingengineering.com/...tool-could-treat-diseases-caused-by-mutations
“It could prove instrumental in developing effective strategies for target-gene replacement of many different types of mutations, and opens the door for using genome-editing tools to possibly cure a broad range of genetic diseases.”
Can this help hair loss science in near future and reprogramming genes associated with Androgenetic Alopecia?
Researchers have developed a new tool -- dubbed SATI -- to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology could be expanded for use in a broad range of gene mutation conditions such as Huntington's disease and the rare premature aging syndrome, progeria.
The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.
Now, Salk Institute researchers have developed a new tool -- dubbed SATI -- to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology, described in Cell Research on August 23, 2019, could be expanded for use in a broad range of gene mutation conditions such as Huntington's disease and the rare premature aging syndrome, progeria.
https://www.sciencedaily.com/releases/2019/08/190823182700.htm
Existing genome-editing approaches, unfortunately, often cause damage. The Salk Institute team says they have created a safer approach.
The new genome-editing technology, recently described in a Cell Research paper, could be used to treat a wide range of gene mutation conditions such as Huntington’s disease and progeria.
The tool, dubbed SATI (Single homology Arm donor mediated intro-Targeting Integration), builds on HITI, a variant of the already established CRISPR-Cas9 gene-editing technique.
As Engadget reports, CRISPR-Cas9 treats mutations by inserting a healthy copy of a problematic gene into the non-coding region of DNA.
SATI, the team says, can perform edits on genes while the mutation is at work. While the DNA is repairing itself, the normal gene becomes integrated into the genome alongside the old one - this eliminates the troublesome gene without the risk of older procedures.
“This study has shown that SATI is a powerful tool for genome editing,” Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper, said in a press release.
https://interestingengineering.com/...tool-could-treat-diseases-caused-by-mutations
“It could prove instrumental in developing effective strategies for target-gene replacement of many different types of mutations, and opens the door for using genome-editing tools to possibly cure a broad range of genetic diseases.”
Can this help hair loss science in near future and reprogramming genes associated with Androgenetic Alopecia?
