Reversal of male-pattern baldness, hypertrichosis, and accel

[squeegee]

Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen.


Benoxaprofen is a non-steroidal anti-inflammatory drug used to
relieve symptoms of rheumatoid arthritis and osteoarthrosis. Reported
side effects include photosensitivity, onycholysis, urticarial rashes and
pruritus, gastrointestinal ulceration and haemorrhage,l and the
Stevens-Johnson syndrome.2 We have reported the development of
toxic epidermal necrolysis, leucopenia, and thrombocytopenic purpura3
in a patient after nine days' treatment with benoxaprofen. We report
here on five patients who developed hypertrichosis and accelerated
hair and nail growth, two of whom showed reversal of male-pattern
baldness

http://www.ncbi.nlm.nih.gov/pmc/article ... ageindex=1

 

[metadalll]

wtf this could be good no?

 

[TravisB]

Wow, this is interesting, although side effects are quite serious. And hypertrichosis - you wouldn't like to look like a werewolf

EDIT: OK, I've seen that it's from 1982, so it's probably nothing special :thumbdown2:

 

[squeegee]

bump.

 

[hairrific]

Someone should try it topically on the scalp. I would use it orally because who wants accelerated body hair growth.

 

[2020]

Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen.


Benoxaprofen is a non-steroidal anti-inflammatory drug used to
relieve symptoms of rheumatoid arthritis and osteoarthrosis. Reported
side effects include photosensitivity, onycholysis, urticarial rashes and
pruritus, gastrointestinal ulceration and haemorrhage,l and the
Stevens-Johnson syndrome.2 We have reported the development of
toxic epidermal necrolysis, leucopenia, and thrombocytopenic purpura3
in a patient after nine days' treatment with benoxaprofen. We report
here on five patients who developed hypertrichosis and accelerated
hair and nail growth, two of whom showed reversal of male-pattern
baldness

http://www.ncbi.nlm.nih.gov/pmc/article ... ageindex=1

didn't I already posted that before?
Looks like it could work but side effects are horrible :woot:

 

[squeegee]

Funny how rheumatoid arthritis medication reverse male pattern baldness...just like Sulfasalazine..

Synovial tissues of patients with rheumatoid arthritis (RA) have increased expression of COX-2. COX-2 expression in most tissues is highly regulated with rapid induction in response to inflammatory stimuli. Anti-inflammatory mediators, particularly glucocorticoids, inhibit up-regulation of COX-2 expression. Increased COX-2 expression in synovial tissues is driven by the pro-inflammatory cytokines IL-1 and TNF-? . These cytokines stimulate COX-2 transcription by activating transcription factors including NF-? B and c/EBP. IL-1 also increases mRNA stability. Modulating influences by other cytokines and growth factors utilize the STAT family of transcription factors. In addition to cytokine networks, signalling via cell surface integrins can increase expression of COX-2. The intracellular pathways triggered by stimulation of integrins include phosphorylation of the ERK kinases.

PGE2, the major PG product of COX-2 in synoviocytes, has been shown to alter matrix metalloproteinase balance and to increase expression of the angiogenic factor, VEGF. In some cell types, constitutive over-expression of COX-2 is associated with phenotypic changes including increased resistance to apoptosis and production of angiogenic factors. To analyze the effect of COX-2 on synovial fibroblast-like cells, we have developed a method for highly efficient constitutive over-expression of COX-2 using a retroviral vector system. Early-passage synoviocytes stably transduced to express high levels of COX-2 can be evaluated for phenotypic changes that contribute to the pathogenesis of rheumatoid arthritis.

 

[DonaldAnderson]

didn't I already posted that before?
Looks like it could work but side effects are horrible :woot:

lol the side effects are horrible woot.

 

[hellouser]

Funny how rheumatoid arthritis medication reverse male pattern baldness...just like Sulfasalazine..

Synovial tissues of patients with rheumatoid arthritis (RA) have increased expression of COX-2. COX-2 expression in most tissues is highly regulated with rapid induction in response to inflammatory stimuli. Anti-inflammatory mediators, particularly glucocorticoids, inhibit up-regulation of COX-2 expression. Increased COX-2 expression in synovial tissues is driven by the pro-inflammatory cytokines IL-1 and TNF-? . These cytokines stimulate COX-2 transcription by activating transcription factors including NF-? B and c/EBP. IL-1 also increases mRNA stability. Modulating influences by other cytokines and growth factors utilize the STAT family of transcription factors. In addition to cytokine networks, signalling via cell surface integrins can increase expression of COX-2. The intracellular pathways triggered by stimulation of integrins include phosphorylation of the ERK kinases.

PGE2, the major PG product of COX-2 in synoviocytes, has been shown to alter matrix metalloproteinase balance and to increase expression of the angiogenic factor, VEGF. In some cell types, constitutive over-expression of COX-2 is associated with phenotypic changes including increased resistance to apoptosis and production of angiogenic factors. To analyze the effect of COX-2 on synovial fibroblast-like cells, we have developed a method for highly efficient constitutive over-expression of COX-2 using a retroviral vector system. Early-passage synoviocytes stably transduced to express high levels of COX-2 can be evaluated for phenotypic changes that contribute to the pathogenesis of rheumatoid arthritis.

Interesting how squeegee touched on rheumatoid arthritis before things like Tofacitinib and Ruxolitinib made headline news against Alopecia Areata.

 

[kirk]

What exactly did he do to get banned? I liked his contributions.

 

[hellouser]

What exactly did he do to get banned? I liked his contributions.

He was extremely offensive to members on the forum.

 

[F2005]

Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen.


Benoxaprofen is a non-steroidal anti-inflammatory drug used to
relieve symptoms of rheumatoid arthritis and osteoarthrosis. Reported
side effects include photosensitivity, onycholysis, urticarial rashes and
pruritus, gastrointestinal ulceration and haemorrhage,l and the
Stevens-Johnson syndrome.2 We have reported the development of
toxic epidermal necrolysis, leucopenia, and thrombocytopenic purpura3
in a patient after nine days' treatment with benoxaprofen. We report
here on five patients who developed hypertrichosis and accelerated
hair and nail growth, two of whom showed reversal of male-pattern
baldness

http://www.ncbi.nlm.nih.gov/pmc/article ... ageindex=1

This should really be made as a topical, which should negate the internal side effects. I realize benoxaprofen has been recalled, but use of a similar drug, like the ones Hellouser mentioned, should be investigated for use as a topical.

 

[folfoxorack]

I would love to try it !