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Authors:
Ali N; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Zirak B; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rodriguez RS; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Pauli ML; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Truong HA; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lai K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ahn R; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Corbin K; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lowe MM; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Scharschmidt TC; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Taravati K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tan MR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ricardo-Gonzalez RR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Nosbaum A; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Bertolini M; Department of Dermatology, University of Muenster, 48149 Muenster, Germany.
Liao W; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Nestle FO; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Paus R; Centre for Dermatological Research, University of Manchester & NIHR Manchester Biomedical Research Centre, Manchester M13 9PL, UK.
Cotsarelis G; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abbas AK; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rosenblum MD; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: michael.rosenblum@ucsf.edu.
Source:
Cell [Cell] 2017 Jun 01; Vol. 169 (6), pp. 1119-1129.e11. Date of Electronic Publication: 2017 May 25.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Abstract:
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregsand HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.
Ali N; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Zirak B; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rodriguez RS; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Pauli ML; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Truong HA; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lai K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ahn R; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Corbin K; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lowe MM; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Scharschmidt TC; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Taravati K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tan MR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ricardo-Gonzalez RR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Nosbaum A; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Bertolini M; Department of Dermatology, University of Muenster, 48149 Muenster, Germany.
Liao W; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Nestle FO; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Paus R; Centre for Dermatological Research, University of Manchester & NIHR Manchester Biomedical Research Centre, Manchester M13 9PL, UK.
Cotsarelis G; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abbas AK; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rosenblum MD; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: michael.rosenblum@ucsf.edu.
Source:
Cell [Cell] 2017 Jun 01; Vol. 169 (6), pp. 1119-1129.e11. Date of Electronic Publication: 2017 May 25.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Abstract:
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregsand HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.
