zephyr31 said:
every supplier iv contacted has said most of the minoxidil will be absorbed after 1 hour. if its not in ur scalp after that it most likely will never be.
its not gradually soaking in over the day like some others seem to think, (according to the producers).
so apply, leave on for 1 hour, wash your hair and style ur hair like a human
.
You are actually not even close. Here is a medical study that Bryan posted here a while back.
J Pharm Sci. 1990 Jun;79(6):483-6.
"Relationship between contact time of applied dose and percutaneous absorption of minoxidil from a topical solution." Ferry JJ, Shepard JH, Szpunar GJ.
"Twenty-two healthy male volunteers completed a four-way, multiple-dose, randomized crossover study to determine the relationship between contact time of applied drug on the scalp and minoxidil absorption from a 2% topical solution. One milliliter of solution was applied twice daily over 150 cm2 of bald scalp to each subject for 6 days. Unabsorbed drug was washed off the scalp after 1, 2, 4, and 11.5 h of contact time in each of four treatments. Cumulative urinary excretion profiles within steady-state, 12-h dosing intervals were well described by straight lines for all treatments, indicating that systemic minoxidil elimination was rate controlled by constant, zero-order percutaneous drug absorption. The extent of minoxidil absorption, expressed as steady-state urinary excretion of unchanged minoxidil, minoxidil glucuronide, or the sum of these, increased in a disproportionate manner with increase in contact time of drug on the scalp.
Relative to the amount absorbed after a contact time of 11.5 h, absorption was approximately 50% complete by 1 h and greater than 75% complete by 4 h. This suggests that minoxidil absorption from the vehicle into skin occurs rapidly relative to diffusion through skin. The rate of minoxidil absorption from vehicle into skin was characterized as nonlinear, whereas minoxidil excretion into urine was rate controlled by diffusion from one or more components of the skin which apparently serve as a reservoir, or depot, for minoxidil."
50% absorption in the first hour, and around 75% by the fourth hour. If you don't wash your hair, your scalp will likely still be absorbing minoxidil all the way up until your next application.