Propecia MUST be safe, if they tried this!

Stinger122

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Overdosage
No adverse effects have been noticed in patients who received single doses of 400 mg finasteride and multiple doses of upto 80 mg/day for three months.

Now come on, if people have used doses that high why the hell would it be so dangerous?

I got this of http://www.inhousepharmacy.co.uk/hair-l ... pecia.html
(says it at the bottom)
 

Dice_Has_Hair

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Stinger122 said:
Overdosage
No adverse effects have been noticed in patients who received single doses of 400 mg finasteride and multiple doses of upto 80 mg/day for three months.

Now come on, if people have used doses that high why the hell would it be so dangerous?

I got this of http://www.inhousepharmacy.co.uk/hair-l ... pecia.html
(says it at the bottom)
Wow. Thats sure is a lot of finasteride. Isn't weird how some people still get side effects. I just wonder if most of those people with the supposed sides are just imagining things.The human mind is a potent weapon. They are just waiting for anything to happen. Ya know what I mean. :shock: :shock: :shock: :eek: :eek: :eek: :hairy: :hairy:
 

Stinger122

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I agree, freaky isnt it?

I do believe the 2% side effects merck state is actually HIGHER but I do believe the side effects do subside with time.
 

Dice_Has_Hair

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Stinger122 said:
I agree, freaky isnt it?

I do believe the 2% side effects merck state is actually HIGHER but I do believe the side effects do subside with time.
I do believe that they subside with time. The body somehow finds a way around it so it can overcome the side effects. I believe I recall HairLossTalk.com saying something like that. Hearing stuff like this puts confidence into the safety of finasteride and usage. Thats what I think. :D :D :D :D :D
 

Stinger122

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Same here Kalika. Nicely put my friend, team work again eh? :p
 

Mr T.

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Stinger122 said:
Overdosage
No adverse effects have been noticed in patients who received single doses of 400 mg finasteride and multiple doses of upto 80 mg/day for three months.

Now come on, if people have used doses that high why the hell would it be so dangerous?

I got this of http://www.inhousepharmacy.co.uk/hair-l ... pecia.html
(says it at the bottom)

Correct me if I'm wrong, but finasteride's effect on DHT is largely independent of dose - so for example, 5 mg doesn't bring DHT levels down much more than 1 mg or even 0.5 mg. So even these colossal doses aren't going to have much more of a significant effect on DHT levels. Therefore, you wouldn't expect problems to develop even with these colossal doses.

On the other hand, there is a higher incidence of recorded side effects at 5 mg as opposed to 1 mg. So maybe this means that all the bad stuff attributed to Propecia occurs through a different mechanism than the lowered DHT levels???

Cheers.

Jeremy
 

Dice_Has_Hair

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Mr T. said:
Stinger122 said:
Overdosage
No adverse effects have been noticed in patients who received single doses of 400 mg finasteride and multiple doses of upto 80 mg/day for three months.

Now come on, if people have used doses that high why the hell would it be so dangerous?

I got this of http://www.inhousepharmacy.co.uk/hair-l ... pecia.html
(says it at the bottom)

Correct me if I'm wrong, but finasteride's effect on DHT is largely independent of dose - so for example, 5 mg doesn't bring DHT levels down much more than 1 mg or even 0.5 mg. So even these colossal doses aren't going to have much more of a significant effect on DHT levels. Therefore, you wouldn't expect problems to develop even with these colossal doses.

On the other hand, there is a higher incidence of recorded side effects at 5 mg as opposed to 1 mg. So maybe this means that all the bad stuff attributed to Propecia occurs through a different mechanism than the lowered DHT levels???

Cheers.

Jeremy
Yes that sounds logical. I've heard of that too. :D :D
 

Stingray

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Finasteride significantly reduces the DHT produced by only ONE form of 5-alpha reductase. If you have a higher concentration of that form opposed to the other form, you will more than likely experience sexual dysfunctions. It doesn't matter if you take 1mg, or 1Kg... you can only inhibit the production of a chemical so much before it just can't be inhibited anymore.
 

Dice_Has_Hair

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Stingray said:
Finasteride significantly reduces the DHT produced by only ONE form of 5-alpha reductase. If you have a higher concentration of that form opposed to the other form, you will more than likely experience sexual dysfunctions. It doesn't matter if you take 1mg, or 1Kg... you can only inhibit the production of a chemical so much before it just can't be inhibited anymore.
Very true. :hairy: :hairy:
 

Mr T.

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Stingray said:
Finasteride significantly reduces the DHT produced by only ONE form of 5-alpha reductase. If you have a higher concentration of that form opposed to the other form, you will more than likely experience sexual dysfunctions. It doesn't matter if you take 1mg, or 1Kg... you can only inhibit the production of a chemical so much before it just can't be inhibited anymore.

This doesn't sound like good science to me, mate. I don't think we can say for certain that the side effects from finasteride are caused by lower DHT levels. Go back and read my last post. Why are there more people experiencing sexual dysfunction with 5 mg of finasteride than 1 mg of finasteride if the amount of DHT inhibition is roughly the same??? I've been thinking that the sides of finasteride are the result of another mechanism independent of DHT levels. Propecia does more than just bring down DHT levels afterall. For example, I read a posted study on that other *helpful* site that says that finasteride affects levels of certain neurotransmitters (er...I think it's the conversion of pregnolone to allpregnolone or vice versa...I'll go and look it up later ; ) ).

Your theory might be true, but it sounds like pure speculation to me.

Cheers everyone.

Jeremy
 

Dice_Has_Hair

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Mr T. said:
Stingray said:
Finasteride significantly reduces the DHT produced by only ONE form of 5-alpha reductase. If you have a higher concentration of that form opposed to the other form, you will more than likely experience sexual dysfunctions. It doesn't matter if you take 1mg, or 1Kg... you can only inhibit the production of a chemical so much before it just can't be inhibited anymore.

This doesn't sound like good science to me, mate. I don't think we can say for certain that the side effects from finasteride are caused by lower DHT levels. Go back and read my last post. Why are there more people experiencing sexual dysfunction with 5 mg of finasteride than 1 mg of finasteride if the amount of DHT inhibition is roughly the same??? I've been thinking that the sides of finasteride are the result of another mechanism independent of DHT levels. Propecia does more than just bring down DHT levels afterall. For example, I read a posted study on that other *helpful* site that says that finasteride affects levels of certain neurotransmitters (er...I think it's the conversion of pregnolone to allpregnolone or vice versa...I'll go and look it up later ; ) ).

Your theory might be true, but it sounds like pure speculation to me.

Cheers everyone.

Jeremy
Keep up the good work. Keep us informed. I always thought that there might be other unknown actions of finasteride. Kinda scary.
 

Mr T.

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kalika said:
Keep up the good work. Keep us informed. I always thought that there might be other unknown actions of finasteride. Kinda scary.

I guess it is kind of scary, but in all fairness, that's true of ALL drugs, not just Propecia.

Cheers.

Jeremy
 

Dice_Has_Hair

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Mr T. said:
kalika said:
Keep up the good work. Keep us informed. I always thought that there might be other unknown actions of finasteride. Kinda scary.

I guess it is kind of scary, but in all fairness, that's true of ALL drugs, not just Propecia.

Cheers.

Jeremy
Yes, you're right! :D
 

Stingray

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Show me some proof for your argument before calling my theory "bad science" ok? Lest the pot be calling the kettle black.

Nerotransmitters won't cause you to grow titties, or cause your dinky not to work correctly. These are all dependant on the male sex hormone Dihydrotestosterone. By altering the supply of DHT to such receptors in the male sex organs, you will alter their functionality... remove too much from the mix, and you will essentially shut it down. It has nothing to do with "neurotransmitters". And if you would like to argue...please pick up any copy of any medical book that deals with the endocrine or reproductive systems.

5-alpha reductase is just a pivotal enzyme that converts testosterone in to DHT. Any direct connection between 1&2-5AR in the brain is just speculation right now.
 

Mr T.

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Stingray said:
Show me some proof for your argument before calling my theory "bad science" ok? Lest the pot be calling the kettle black.

Err...I DID show you some proof. Go back and read my post. Once again, DHT levels are almost equally lowered whether you're taking 1 mg or 5 mg. However, there is a higher incidence of side effects with 5 mg. I've been thinking that finasteride side effects, at least the sexual ones, are caused by some other mechanism than lowered DHT levels. That may or may not be true, that's just my theory. But I at least presented some evidence for it. You didn't do so with your "theory," which was really just speculation stated as fact. Now if you had said that this was your opinion, that would have been fine, but you completely failed to do so.

Stingray said:
Nerotransmitters won't cause you to grow titties, or cause your dinky not to work correctly. These are all dependant on the male sex hormone Dihydrotestosterone. By altering the supply of DHT to such receptors in the male sex organs, you will alter their functionality... remove too much from the mix, and you will essentially shut it down. It has nothing to do with "neurotransmitters". And if you would like to argue...please pick up any copy of any medical book that deals with the endocrine or reproductive systems.

*Sigh* I don't think you even read my post, so I'd encourage you to go back and read it before you go any further.

Ok, did you read it? Good. Let me continue then.

Now, I didn't say that neurotransmitters will cause you to "grow titties" or anything else. IF neurotransmitters were somehow related to Propecia side effects, it would be as a result of LOWER LEVELS of neurotransmitters, not the neurotransmitters themselves. But I suspect this is what you meant and you just worded your thoughts poorly.

However, I didn't even say that there was a connection between LOWER LEVELS of neurotransmitters and Propecia side effects. At least not sexual side effects and gyno. I have read accounts of people complaining of memory problems however, and there just might be a connection there. My point was that drugs have more than one effect on the body, and I just wanted to provide an example that Propecia does more than just lower DHT levels. So, Propecia could be doing things that we don't know about just yet, and it could be one of these things that are responsible for the side effects, do you follow? I thought this was pretty clear. Either I was wrong, or you need to work on your reading comprehension skills, mate.

Now, DHT is important for male sexual development. However, it's not known if DHT is necessary for male sexuality after puberty. It would seem that it is important, because there are receptor sites for DHT in the penis. But look at guys taking Avodart. They have their DHT levels lowered by up to 90% or so, and most of them don't have side effects (although there is a higher incidence of side effects than with finasteride). Now that's just amazing. Imagine if you were to lower testosterone levels up to 90%. Imagine what THAT would do to your willy!

If lowered DHT levels are responsible for sexual dysfunction, it's still a complicated process which you oversimplify (without any evidence at all) by saying that if you have a higher concentration of type 2 DHT then you will experience sexual dysfunction. How do you know that? If you don't have any evidence to cite, then don't state something as fact - make sure you clarify that it's just your opinion.

Cheers.

Jeremy
 

Mr T.

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Stingray said:
5-alpha reductase is just a pivotal enzyme that converts testosterone in to DHT. Any direct connection between 1&2-5AR in the brain is just speculation right now.

Almost forgot this. Actually, 5ar is the enzyme responsible for the conversion of pregnolone to alpregnolone. Or maybe it's the other way around. I'll look it up later and post the study if you want to read it.

Jeremy
 

Mr T.

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Stinger122

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Wow Mr.T you certainly know your stuff! And it DOES make sense with all of what you said!

Glad we have someone as knowledgable as you on board :p
 
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