Propecia and androgen receports

[jimmystanley]

does anyone know if propecia causes more hypersensitivity in our androgen receptors on our scalp (or more follicles to become sensitive to DHT) ? Or if this returns to normal if you stop? I've done research and found no conclusions.

 

[Bismarck]

The hyperandrogenic reflex: Some say that it doesn't exist at all, others are sure that they're suffering from it.

The question is: If the body adapts to the decreased DHT level in the blood by upregulating androgen reception, is this upregulation high enough such that 30% remaining DHT is able to damage the follicle more than 100% DHT without upregulation of androgen receptors ?
I did search for this phenomenon too but I couldn't find something with a scientific background. (Don't expect Merck doing sth. like that)

Intuitively, I would say if the body is able to upregulate the receptors he should also be able to downregulate them. Hence, the effects of the reflex should disappear after stopping with Finasteride.

Perhaps could the reflex be avoided if you slowly increase the dosage of Finasteride if we consider the reflex as a "shock reaction".

BIS

 

[jason566]

like maybe say start off on .25mg every other day the first week then every day the second and slowly work up to 1mg?

 

[justasking]

I did that but, once I got to 1 mg., I had the reaction anyway. But that's just me.

 

[Bismarck]

justaking, how are you?
I remember you having severe side effects from finasteride. Did you continue with finasteride?

BIS

 

[jimmystanley]

moi? I'm not sure how propecia is working for me. I've had bad seborrhea for a while and lots a ton of hair. it's really hard to say. i have diffused thinning

 

[Bismarck]

like maybe say start off on .25mg every other day the first week then every day the second and slowly work up to 1mg?

That could help. But the body could also increase the receptors proportionally to the dose.
I really don't know what to think about this reflex. It reminds me to the not reversible damages minoxidil can cause to the follicle.

BIS

 

[jason566]

reversible damages minoxidil can cause to the follicle

what damage and where did u read minoxidil causes damage?