Proliferation, DNA repair and apoptosis in Androgenetic Alopecia

[bornthisway]

Proliferation, DNA repair and apoptosis in androgenetic alopecia

J Eur Acad Dermatol Venereol. 2009 Jan;23(1):7-12.
Department of Dermatology, Faculty of Medicine, Al-Minya University, Al-Minya, Egypt. El-Domyati M, Attia S, Saleh F, Bassyouni MI, El-Fakahany H, Abdel-Wahab H.

BACKGROUND: Androgenetic alopecia is a common hair disorder, resulting from interplay of genetic, endocrine and ageing factors. Meanwhile, it is unclear if an altered degree of proliferation or increased apoptosis could contribute to its pathogenesis. OBJECTIVE: To evaluate the role of proliferation, DNA damage and apoptosis in the pathogenesis of androgenetic alopecia. METHODS: Thirty biopsies were taken from the frontal (bald) area and occipital (hairy) area of 15 male patients with androgenetic alopecia, as well as five specimens from frontal area of five age-matched controls. These specimens were used for immunohistochemical staining of cell proliferation [proliferating cell nuclear antigen (PCNA)] and DNA repair markers (XRCC1, APE1, PARP-1) as well as apoptosis regulatory protein p53. RESULTS: The frontal bald area of patients showed significantly higher levels of X-ray Cross Complementing-1 (XRCC1; P<0.001) and p53 (P<0.001) expression when compared with occipital hairy area of patients and frontal area of controls (P=0.003 and 0.04, respectively). On the other hand, there were significantly lower expression of PCNA (P<0.001) and apurinic/apyridinic endonuclease 1 (APE1; P=0.001 and 0.02) when compared with the frontal area of controls and occipital area of patients, respectively. Meanwhile, APE1 showed significant inverse correlation with p53 overexpression (P=0.03). CONCLUSION: The frontal bald area of patients with androgenetic alopecia has lower proliferation rate that result in follicular miniaturization. There is increased DNA damage that would be beyond the capacity of cells to repair in advanced cases. An alternative pathway would take place in order to eliminate the damaged cells through apoptosis.

 

[goata007]

I don't have access to the full study. But can anyone explain what exactly they mean by "advanced cases". I'm in my 20s with NW6, does that count as an advanced case? or does a person with NW6-7 for 10 years or so counts as an advanced case?

I have dense coat of vellus hairs all over my NW1 area, if all my vellus hair turned to terminal I would get all my hair back!

 

[SoThatsLife]

I don't have access to the full study. But can anyone explain what exactly they mean by "advanced cases". I'm in my 20s with NW6, does that count as an advanced case? or does a person with NW6-7 for 10 years or so counts as an advanced case?

I have dense coat of vellus hairs all over my NW1 area, if all my vellus hair turned to terminal I would get all my hair back!

I have often seen that they write "advance balding" on a slick bald head. Many researchers believe that the follicle is still alive under the skin even if it's not visible, but I think the longer since it has been hair(vellus) on ones head, the harder it would be to actually make them back to terminal hair. The hedge hog project supposedly regrow hair on bald scalps, but i really don't know how and if it was tested on humans.

I know you follow the "other forums", and I think the Baccy experience shows that you could regrow(or maybe even rejuvinate or make new hairs) hair even if one has been slick bald for years. Just so annoying that follica keeps the cards so close to the chest. But one could speculate that they are really afraid that the procedure is quite simple if one does it correctly, so they don't want the public to know how its done.

It would be a cool experiment if you bought Proxiphen and Xandrox/minoxidil 15% and tested it at a shinny area for 6 months.

 

[goata007]

I have often seen that they write "advance balding" on a slick bald head. Many researchers believe that the follicle is still alive under the skin even if it's not visible, but I think the longer since it has been hair(vellus) on ones head, the harder it would be to actually make them back to terminal hair. The hedge hog project supposedly regrow hair on bald scalps, but i really don't know how and if it was tested on humans.

I know you follow the "other forums", and I think the Baccy experience shows that you could regrow(or maybe even rejuvinate or make new hairs) hair even if one has been slick bald for years. Just so annoying that follica keeps the cards so close to the chest. But one could speculate that they are really afraid that the procedure is quite simple if one does it correctly, so they don't want the public to know how its done.

It would be a cool experiment if you bought Proxiphen and Xandrox/minoxidil 15% and tested it at a shinny area for 6 months.

I'll just write the reserachers an email and ask them about it. My hairloss was aggressive but it's been less than 5 years ago that I used to have a relatively full head of hair! That's why I really want to regrow my existing hair and not have to worry about creating new ones.

Yea, I am active on several forums with the same screenname I agree with you about Follica, they're being way too secreative. Their patent is valid globally, so no one can steal their idea for commercial purposes. The only people who desperately want to know more about their procedure are people like me & Baccy, and we have no commercial interest in their procedure at all. We just want our, at least some of, hair back and move on with our lives.