Post-finasteride/dutasteride-syndrome Exists (my Experience)

[Moosey]

I just want to say that personally i believe in temporary Post-Finasteride-Syndrom (PFS) by now. I was one of the people who made fun of it, and i even made fun of the idea that finasteride could even create side effects in the first place. Now this anecdotal experience from me is with dutasteride, but this might apply to finasteride for some people who are even more sensitive than me.

I took dutasteride for 10 months. During those months, my libido was non-existant. A woman could be fondling me and i wouldnt be able to get hard. No issue for me. I just wanted to get some of my hair back and then stop the drug. The dutasteride did work. Not to the extent i expected, but it worked. I stopped the dutasteride and waited for my libido to come back. 1 months - > nothing. 2 months -> nothing. To be expected considering the drugs half life. But then, this pattern continues. 3 months, 4 months. 5 months. My libido is still gone. As i planned to start my long, low dose steroid cruise soon anyways, i decided to start with it earlier than planned to see if it would help me. 250mg of test decanoate per week. Fast forward 2 months, i can feel improvements in my libido. But it basically went from 0% to 20-30%, which is obviously not enough. I waited another 2 months. 40% libido now, which is still laughable compared to before.
I want to point out i never had libido issues in my life. During my cycles, during my PCT's when my Testosterone was low. Never.

So researched the topic to find out whats wrong. Why is my dick not working, despite getting bombarded with so much testosterone and DHT?
Your penis is made up of smooth muscle which contracts or relaxed to control the blood flow rushing into your penis. DHT is the primary androgen in this smooth muscle. Its one of the only muscles in the body that relies on DHT. Or should i say, androgenicity. Based on your genetic suspectability, people require different DHT levels (or androgen activity) to maintain this smooth muscle. If you are sensitive to low androgenic activity in your genitalia, the muscles will atrophy and literally lose size and strength. Its the primary reason why PFS as a topic exists at all. When this muscle atrophies, it needs DHT and literal training to get back to its old form. Which is fapping, as stupid as that sounds.

Again, i want to point out, i never ever had libido issues in my life. Im healthy, i lift 4 times a week. Im a happy person. I was never stressed out about my libido and never worried about side effects (for the people who would claim "placebo"). And i still experienced such severe side effects.
Now look at the extent i had to go and the timeframe to recover just a tiny bit. The amount of hormones and medications im using to create the perfect envinvronment for libido.
Imagine what happens to people who dont have access to these things, or are simply not ready to go to this extent. I can understand how someone claims Post-Finasteride-Syndrome when he still has libido issues 2 years after discontinuation.
Yes, this happened with dutasteride. But there might be people who are even more sensitive than me and get these issues on finasteride.

The big mistake for me was taking dutasteride and thinking i would recover on my own. The half life is too long. Take finasteride instead. When you notice severe side effects, the drug will be out of your system in mere days when you stop. It also not nearly as strong as dutasteride.

I know some people are going to call me a beta or something, or tell me i didnt drink enough water, or that i didnt sleep enough or some other kind of excuse to give a reasoning for my side effects other than dutasteride. I should have been one of the last people to get side effects but i still got them.
I know this goes against research data but i can only share my experience and tell you what happened in my case. Some people are just very unlucky. Some people are immune to finasteride. Some people are immune to libido issues. Some people watch p**rn and their dicks stop working. Some people take pro-level amounts of steroids for 20 years and dont lose hair. All these things seem impossible but they seem to exist.

 

[INT]

?

 

[TomRiddle]

Lmao, all the finasteride fanatic incels are coming back and crying about sides but only after they argued and offended anybody who would say something bad about finasteride before they took it. Typical and you can see this all over the internet, on every hair loss forum, the best one was that guy that @Pigeon found, that was the most documented finasteride guy i ever saw in my life, it almost convinced me to try it, luckily i followed the thread and after 5 years and 100 pages, he said that taking finasteride and actually believing the studies and safety profile, was the biggest mistake of his life...

 

[INT]

Lmao, all the finasteride fanatic incels are coming back and crying about sides but only after they argued and offended anybody who would say something bad about finasteride before they took it. Typical and you can see this all over the internet, on every hair loss forum, the best one was that guy that @Pigeon found, that was the most documented finasteride guy i ever saw in my life, it almost convinced me to try it, luckily i followed the thread and after 5 years and 100 pages, he said that taking finasteride and actually believing the studies and safety profile, was the biggest mistake of his life...

You have a link to that thread?

 

[TomRiddle]

You have a link to that thread?

@Pigeon linked it to me but they banned me and lost all my history somehow, i have to scroll through all my messages and i don't have time for that but maybe @Pigeon saved it and he could give it to us once more if he does not mind...

 

[TomRiddle]

Yup, you're talking about the bodybuilding.com guy right? True eye opener for anyone who's on the fence of taking fina or not.

Yeah that one, please post the link again if you have it i want to bookmark it. Many thanks

 

[TomRiddle]

@INT Here you go: https://forum.bodybuilding.com/showthread.php?t=158889153

Guy who started the thread Redstar was convinced fina was "safe" just like most of the coping bro scientists here. After a couple of years he got pfs and even ended on propeciahelp.

Most complex guide and documentation i have ever seen made by a random user about finasteride, with every study, very in dept scientific information and logical arguments. And with all that to end up on propecia help with pfs, it must really suck to lose at the russian roulette after thinking that the chances are that low as these fanatics incels like to think they are, and this is because of the misleading and full of conflict of interest studies made by the hair loss industry that thrives and grows on peoples misery, stupidity and ignorance... And this comes into play for transplants also not just for the studies financed by Merk and co, because if you look at the hair restoration forum, 99% of the results are based on transplants of people who take or have taken finasteride, the rest without are looking like complete sh*t, and this shows clearly why the transplant industry started financing biased and full of interest finasteride studies...

You could also check this, everybody who really wants to be informed about this medication should have access and read this info, that's if they are not in the group that reads only what fits their delusional narratives of course...

The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064044/

Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.

RESULTS:
Of 34 clinical trials, none had adequate safety reporting, 19 were partially adequate, 12 were inadequate, and 3 reported no adverse events. Funnel plots were asymmetric with a bias toward lower odds ratio for sexual adverse effects, suggesting systematic underdetection. No reports assessed adequacy of blinding, 18 (53%) disclosed conflicts of interest, and 19 (56%) received funding from the manufacturer. Duration of drug safety evaluation was 1 year or less for 26 of 34 trials (76%). Of 5704 men in the clinical data repository who were treated for Androgenetic Alopecia with finasteride, 1.25 mg/d or less, for Androgenetic Alopecia, only 31% met inclusion criteria for the pivotal trials referenced in the manufacturer's full prescribing information and 33% took finasteride for more than 1 year.

CONCLUSIONS AND RELEVANCE:
Available toxicity information from clinical trials of finasteride in men with Androgenetic Alopecia is very limited, is of poor quality, and seems to be systematically biased. In a cohort of men prescribed finasteride for routine treatment of Androgenetic Alopecia, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for Androgenetic Alopecia. Published reports of clinical trials provide insufficient information to establish the safety profile for finasteride in the treatment of Androgenetic Alopecia.

https://www.ncbi.nlm.nih.gov/pubmed/25830296

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.692.4105&rep=rep1&type=pdf

 

[Moosey]

I deleted my post and still started a discussion lol thats funny.
I edited my original post and typed out the text again, its too late now anyways

 

[TomRiddle]

We already saw you crying about sides a while ago, here and on reddit, and this after you were one of the finasteride advocates and one of those who insulted people having sides and so on. So what's funny is that you still have the nerve to think that people having lives destroyed by this treatment or people including you having serious sides on the medicine is funny, and that is mind blowing and shows clearly what most of you incels think or what mentalities you have.

Ignorance, stupidity, mockery, insults, even after you see that you were wrong and even when there is proof right in front of your eyes... But you know how it is, in the end, we all suffer the repercussions of our own actions, don't be fooled by the calm before the storm in thinking that somebody will actually skip the suffering part, even if for some comes later than others.

 

[TomRiddle]

I am not emotionally invested not even in my personal balding head, but that's just me, i always try to keep my head up and mentality at it's strongest peak because i was raised to understand that life is not easy and that anytime something could go wrong and bring havoc into my life. We need to handle it regardless of what it is and when the time comes, we will die anyways... But this is not the point and i am happy to see this guys post for example, because he started by saying that he was one of those who did not even f*****g believe that sides could happen or exist from this medication, and only having the courage to admit that he was one of them, shows he has more character than the others who don't even admit having sides and so on.... So more power to him and i really hope nobody has to go through something life altering or that causes distress and health problems, regardless of what tranny medicine they are taking.

But for the ignorant delusional mental ill ones unfortunately there is no escape because they are trapped inside their own shitty ill mind and until they seek help, professional help i mean, they won't solve nothing and be in the same situation, until they will die eventually. And it's a pity, because none deserves to die, regardless of their illnesses and so on, and i'm not talking here about criminals, pedos etc, i'm just clarifying for the low iq ones that can't understand an example or analogy...

 

[Ikarus]

I want to stop taking dutasteride, but I don’t know if it will induce a shed.

 

[Ikarus]

Most complex guide and documentation i have ever seen made by a random user about finasteride, with every study, very in dept scientific information and logical arguments. And with all that to end up on propecia help with pfs, it must really suck to lose at the russian roulette after thinking that the chances are that low as these fanatics incels like to think they are, and this is because of the misleading and full of conflict of interest studies made by the hair loss industry that thrives and grows on peoples misery, stupidity and ignorance... And this comes into play for transplants also not just for the studies financed by Merk and co, because if you look at the hair restoration forum, 99% of the results are based on transplants of people who take or have taken finasteride, the rest without are looking like complete sh*t, and this shows clearly why the transplant industry started financing biased and full of interest finasteride studies...

You could also check this, everybody who really wants to be informed about this medication should have access and read this info, that's if they are not in the group that reads only what fits their delusional narratives of course...

The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064044/

Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.

RESULTS:
Of 34 clinical trials, none had adequate safety reporting, 19 were partially adequate, 12 were inadequate, and 3 reported no adverse events. Funnel plots were asymmetric with a bias toward lower odds ratio for sexual adverse effects, suggesting systematic underdetection. No reports assessed adequacy of blinding, 18 (53%) disclosed conflicts of interest, and 19 (56%) received funding from the manufacturer. Duration of drug safety evaluation was 1 year or less for 26 of 34 trials (76%). Of 5704 men in the clinical data repository who were treated for Androgenetic Alopecia with finasteride, 1.25 mg/d or less, for Androgenetic Alopecia, only 31% met inclusion criteria for the pivotal trials referenced in the manufacturer's full prescribing information and 33% took finasteride for more than 1 year.

CONCLUSIONS AND RELEVANCE:
Available toxicity information from clinical trials of finasteride in men with Androgenetic Alopecia is very limited, is of poor quality, and seems to be systematically biased. In a cohort of men prescribed finasteride for routine treatment of Androgenetic Alopecia, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for Androgenetic Alopecia. Published reports of clinical trials provide insufficient information to establish the safety profile for finasteride in the treatment of Androgenetic Alopecia.

https://www.ncbi.nlm.nih.gov/pubmed/25830296

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.692.4105&rep=rep1&type=pdf

All of this can be avoided by using particular NSAAs!

 

[Moosey]

I want to stop taking dutasteride, but I don’t know if it will induce a shed.

You are on a full blown tranny regimen. How can you have the desire to stop dutasteride while using 50mg of oral bicalutamide and 2mg of estradiol?
If your dick is still working (or you dont care), keep going. I would up the estradiol though, its quite low

 

[justbeconfident]

I want to stop taking dutasteride, but I don’t know if it will induce a shed.

Why do you want to stop taking it

 

[Ikarus]

You are on a full blown tranny regimen. How can you have the desire to stop dutasteride while using 50mg of oral bicalutamide and 2mg of estradiol?
If your dick is still working (or you dont care), keep going. I would up the estradiol though, its quite low

I mean, I want to drop the dutasteride because it may not be entirely required since I’m on a strong regimen already. But, I’m not sure if stopping it may or may not induce a shed. I wouldn’t increase my dosage of E since my levels are almost at 1000 pmol/L from 2mg currently, which could mean I have a sensitivity to E.

Why do you want to stop taking it

Concerns of inhibiting 5AR when clinical depression already exists; it may or may not be worsening my depression. Bicalutamide increases dutasteride blood levels, resulting in increased 5AR inhibiting.

 

[Moosey]

I mean, I want to drop the dutasteride because it may not be entirely required since I’m on a strong regimen already. But, I’m not sure if stopping it may or may not induce a shed. I wouldn’t increase my dosage of E since my levels are almost at 1000 pmol/L from 2mg currently, which could mean I have a sensitivity to E.



Concerns of inhibiting 5AR when clinical depression already exists; it may or may not be worsening my depression. Bicalutamide increases dutasteride blood levels, resulting in increased 5AR inhibiting.

That makes sense. Do you take the E sublingual or orally? 1000pg/ml is insane. The MTF on reddit get mere 50-150pg/ml at that dose.
I took 4mg for 2 weeks sublingual and got literally no itchy/tingling sensation in my breast tissue

 

[Ikarus]

That makes sense. Do you take the E sublingual or orally? 1000pg/ml is insane. The MTF on reddit get mere 50-150pg/ml at that dose.
I took 4mg for 2 weeks sublingual and got literally no itchy/tingling sensation in my breast tissue

Im using it buccally, I put it between my cheek and gum before I go to bed. In pg/mL, it’s around 270 pg/mL. In pmol/L, it’s at 1000. Did you get any changes from using E for 2 weeks? So far, there has been 1 person who got no gyno from 4mg of E

 

[TomRiddle]

All of this can be avoided by using particular NSAAs!

Lol, dude, with all due respect, do you have any proof of some sort that can sustain your statement or it's just your own personal opinion? It's a site called post finasteride that has tried absolutely everything to get back to normal. It's true that some maybe got back to normal using some sort of treatments, NSAAs and many other things, there are some that get better or revert to normal without nothing, naturally, their bodies heal with time, but it's not the case for the majority. From the desperation, some poor fucks even tried finasteride again, different doses combined with different other things, just in case it could give them or the doctors a sign of something that maybe it's missed or maybe it could reset somehow, but as they said, it was the biggest mistake you could do, if you suffer from persistent or permanent damage...

And before somebody starts calling them freaks, insane, mentally ill, etc you could first look in the mirror and analyze your own lives, history and behavior and after you could check their thread called "Let's get to know eachother" or something like that, they made it especially to give details of their lives including their history including photos so that people stop thinking or assuming that they are some kind of rarity amongst the finasteride users...

If you take a look there you will see that there are a lot of people that are over the average of normality, from doctors to race car pilots who just wanted to keep their hair and trusted their doctors and studies just like most of people do, without doing any further or deep research after that. They were normal, most without any kind of medical histories or problems, they just took the f*****g pills because they are approved and the only things working, at least from the approved ones... That should make anyone think about it, regardless of their after decisions, at least you know what to expect, it would minimize the impact more if something happens...

 

[FilthyFrancis]

I find it crazy people are still denying PFS today. The fact it is still on the market today means health authorities consider it to bear a positive risk/benefit ratio, despite all the recent noise from PFS sufferers.

If there were to be a debate, it should be around whether this ratio is positive. I mean... the stakes are high... It is a real Russian roulette we are playing with this drug. Not everybody will suffer from permanent sides but for the ones who do, Finasteride is one of life's worst decisions ever made.

Seeing youngsters, aged 16-20, jumping on this pill - driven by their own insecurity - is killing me. For I am not sure they are mature enough to ponder this risk/benefit equation.

@OP Thanks for giving feedback. Prevention is not a luxury.

I look forward to finding alternatives that will push this drug out of the market.

 

[TomRiddle]

I find it crazy people are still denying PFS today. The fact it is still on the market today means health authorities consider it to bear a positive risk/benefit ratio, despite all the recent noise from PFS sufferers.

If there were to be a debate, it should be around whether this ratio is positive. I mean... the stakes are high... It is a real Russian roulette we are playing with this drug. Not everybody will suffer from permanent sides but for the ones who do, Finasteride is one of life's worst decisions ever made.

Seeing youngsters, aged 16-20, jumping on this pill - driven by their own insecurity - is killing me. For I am not sure they are mature enough to ponder this risk/benefit equation.

@OP Thanks for giving feedback. Prevention is not a luxury.

I look forward to finding alternatives that will push this drug out of the market.

We all look forward friend, that's for sure. Unfortunately, the industry, media, etc bla bla will always benefit and take for granted everything, especially young ones insecurities. The younger you are, the easier to manipulate, especially if you don't have some kind of "father/mother or both figure" around you. It's so easy today to get drugs that could destroy your life over the internet with a click, but i'm sure that most are aware of this, not wanting to talk about the blindness in which people are trusting studies without knowing or informing themselves about who financed them, why and how they were conducted, from start to finish...

Welcome to 2020, where angry virgins kill people because they can't get pussy, where in the US is an epidemic of opiates that is killing thousands a year or maybe even more, in the UK for example, there were 70 million antidepressants prescriptions were given only last year, and i could go like this until i die, showing and pointing out the things that got us here, but who really cares, when the majority is formed out of sheep that do the same thing over and over again without having any will of using their brains, even for a small amount of time... That's why the best thing you could do, even if it's the selfishest thing to do, is to take care of yourself and your close ones. Do your own research, take your conclusions and move on, it's very hard to even try to save someone else, especially as most are very deep buried in their own mindset which tells them to refuse everything that does not fit their narratives...