Nizoral 1% question

[LowGman]

Hey everyone.

I have a Nizoral 1% shampoo question

Does Nizoral function in the way that minoxidil does in the sense that......

Once you stop the application of minoxidil, you loose whatever gains you have made with it.
I'm a Norwoord 1.5 (boohoo I know), with some thinning on the right corner of my hairline. I'm on no treatments, and I just started using Nizoral.

I understand Nizoral is to prevent the binding of DHT, and not used for regrowth. If Nizoral successfully blocks the DHT to the area in which I apply it,will all of these hairs become dependent on the nizoral and jump ship once they are not getting the nizoral? Or if I stop using the product, will the DHT just resume it's natural course toward the hair in that area.

I understand : No nizoral= The hairs are gonna get more DHT
With nizoral= Some of the DHT with be blocked from binding

I just don't know if using nizoral will create "artificial, treatment dependent gains" in the way that minoxidil does.

I hope my question is clear, any help is appreciated.
Thanks.

 

[Quadzilla99]

No one knows. People will give you answers here based on guesswork most likely...but there haven't been studies done to evaluate that Nizoral is a potent anti-androgen but we still don't even understand exactly what its moa is...it inhibits inflammation which is a problem in male pattern baldness so that may even be the reason it works.


Here's a collection of all the Nizoral studies I could find I know of:


1%:


Reduces shedding and makes hair thicker:


Nudging hair shedding by antidandruff shamp... [Int J Cosmet Sci. 2002] - PubMed - NCBI


Effetti di uno shampoo al ketoconazolo sulla calvizie androgenetica


2%:


Almost as effective as 2% minoxidil:


Ketoconazole shampoo: effect of long-term use in... [Dermatology. 1998] - PubMed - NCBI


(nizoral + Propecia more effective than Propecia alone):


Comparative efficacy of various treatment regimen... [J Dermatol. 2002] - PubMed - NCBI


21 month study with graph (best results seen from months 6-15):


2% Nizoral Shampoo Increases Hair Growth in Men with Male Pattern Baldness


Small Japanese 2% cream study with before/after photos of two subjects:


http://www.hairsite.com/hair-loss/forum_entry-id-25116-page-0-category-0-order-last_answer.html


Scientists shaved mice repeatedly and applied either ketoconazole or a vehicle solution to their skin and the mice who received ketoconazole repeatedly demonstrated "a macroscopically significant stimulatory effect". In other words their hair grew like crazy.


Topical application of ketoconazole stimulates ha... [J Dermatol. 2005] - PubMed - NCBI


Others:


Ketocazole as an adjunct to finasteride in th... [Med Hypotheses. 2004] - PubMed - NCBI


Oral ketoconazole is such a potent anti-androgen its basically castration in a bottle:


Effect of ketoconazole and other imidazole fungicides on testosterone biosynthesis


Low-dose ketoconazole treatment in hirsu... [J Endocrinol Invest. 1990] - PubMed - NCBI


[Efficacy of low dose ketoconazole th... [Zhonghua Yi Xue Za Zhi. 2012] - PubMed - NCBI


[The effect of nizoral on the function of the hyp... [Lik Sprava. 1992] - PubMed - NCBI


It doesn't get absorbed enough from topical application to do any of that though:


Clinical pharmacokinetics of ketoconazole. [Clin Pharmacokinet. 1988] - PubMed - NCBI


and yet another early study on topical keto (det I can't find right now) showed that serum levels of ketoconazole were virtually undetectable even when they used large doses

 

[LowGman]

I appreciate the response, as well as the links.

Thanks.