Negative side effects of dutasteride

[mattam]

Hi,

Heard stories here and there that dutasteride is a "powerfully scary" drugs with some potential hideous side effects.

However, reported side effects on Avodart's site is similar to that of finasteride.

AND, I just thought of another argument/question. Would appreciate if anyone here has useful source of info or correct me if I am wrong.

- Is dutasteride considered scary because 1) it works on both of 5-alpha reductase? Or 2) is it because it reduces so much DHT (nearly eliminates it).

If 2), then one fact may go against that -- CASTRATED men should theorhetically be devoided of DHT (as they completely lack testosterone to be converted to DHT).

So, if CASTRATED men (as in ancients Italian's Castrati singers), lived long and healthy lives (albeit lacking any sex drives), then total elimination of DHT should theorhetically not post serious health risk.

Of course, there's the question of sexual side effects. And then, whether castrated men have been studied long enough, large enough sample size, etc.

But this should be another interesting argument for safety of dutasteride in terms of elimination of DHT.

 

[Buffboy]

Peter Mac said this on the subject:

Dutasteride triggers a chain of pharmacological actions different than finasteride. I know many patients that switched and had worse results with dutast. Now dutast supposedly inhibits more 5-ar than Propecia so in theory the results should be better. But the body is a complicated machine and our logical theories don't always pan out.
I know many patients that switched to dutast only to switch back to
finast.

I'd like to see long term studies as well. Last time I checked they couldn't account for how 50% of the dutast was metabolized by the body.
Where is it going? Now that's a little scary. We're talking world leading
chemists have no idea where this drug is going in the body.

 

[ropcat]

Buffboy- Forgive my ignorance, but who is Peter Mac?

 

[Buffboy]

Buffboy- Forgive my ignorance, but who is Peter Mac?

Just some guy who is widely respected over at hairlosshelp.com. I was so lucky that I ran into him this summer when I had my hair transplant done. I trust him a lot.

 

[drinkrum]

Peter Mac said this on the subject:

Dutasteride triggers a chain of pharmacological actions different than finasteride. I know many patients that switched and had worse results with dutast. Now dutast supposedly inhibits more 5-ar than Propecia so in theory the results should be better. But the body is a complicated machine and our logical theories don't always pan out.
I know many patients that switched to dutast only to switch back to
finast.

I'd like to see long term studies as well. Last time I checked they couldn't account for how 50% of the dutast was metabolized by the body.
Where is it going? Now that's a little scary. We're talking world leading
chemists have no idea where this drug is going in the body.

My feelings are similar to Mac's on this topic. Remember, as I have stressed before, that the 5-AR I isozyme, that dutasteride inhibits, is found in the myelin sheath of neural cells. This is a potentially scary thought.

D.

 

[Buffboy]

Re: .

what about if I apply dutasteride topically? will it reduce the side effects? will it be the same effective?

It will most def. reduce/eliminate the side effects. I don't know about its efficiancy though.

 

[mattam]

Two thoughts:

1) "I know many patients that switched and had worse results with dutast...."

I assume patients that decide to switch are those that finasteride is not currently working for them. Otherwise, if it works well, why would they switch??? So, the fact that they "may have" worse results could just be that they are at the point where DHT blocking, no matter how much, does not really help them and they are progressing on male pattern baldness. So dutasteride is still effective at blocking DHT more so than finasteride but just not helping.

2) " ...couldn't account for how 50% of the dutast was metabolized by the body...."

So, it seems, the perils of dutasteride is more on not knowing how the drug is metabolized in the body, but NOT on the fact that it inhibits different type of 5-AR. Because in latter case, my argument on Castrati would go against it....????