Need a big favor. S Foote's theory in a nutshell?

[Armando Jose]

Thank you Michael for you time:

In This picture, http://www.drvogelplasticsurgeon.com/bna/hair_08.html . The texts say:
“He was so unhappy with the result of the transplant that he shaved the grafts down and wore a hair piece to cover them.â€

A hair piece can act as an absorbent surface, Ok? So, it is possible that sebum doesn’t accumulate and degrade.


http://www.hairsite.com/hair-loss/forum ... hp?id=6284
In this case, transplanted hairs have a sufficient length and comb in order to touch among them.
The same with your cited links http://brandymd.com/hair_transplant_photos.cfm and
http://www.drvogelplasticsurgeon.com/hair transplant ... corrective

Normally hair transplanted grows at sufficient length in order to cover the more scalp surface possible. All of them have more than 5 centimetres of length.


http://images.salon.com/opinion/blument ... /story.jpg,
I am sorry but the link don’t work

Yo say:
“The vertex bald spot. The classic vertex bald spot on your head should about half-way rest on a pillow at night, yet it goes bald...........why?â€

Your comment is very interesting.
The whorl in the vertex is a special zone where the angle and orientation of hair change quickly. The effect is an increasing in the independency of hairs and so it is more probable that sebum flow is interrupted. The same thought for person with a high scalp hair density and high hair thickness, who even with short hair don’t develop problems with sebum flow. In a nutshell, there is two ways of eliminating sebum from the hair shaft, a longitudinal along the hair fibre and a second transversal due to the intimae contact among scalp fibre hair. It is interesting note that senior women that made a lot of perms are more vulnerable to common hair loss because this hairdresser work make that hairs don’t touch among them, in order to give more hair volume. Do you agreed?

You say: “..................................Armando are you suggesting the increase in androgen receptors and increase in DHT that we see in balding scalp is due to SEBUM BACK UP????????????????????????? All those cellular processes involved can be traced back to sebum back up!!!!!!!!!!!!!!!!!!!>>>??????????????????????????????????///â€

No really. But sebum have and transport androgens, do you know?
If sebum flow is blocked in anyway, the androgens concentration can vary and then develop a hormonal dysfunction.

You say: “Yours is the most pathetic baldness theory to date Armando.â€
It is possible even that Ockham razor is wrong. My theory is based in the equality of all healthy hairs over the scalp, and you refer to the distinctive androgen sensitivity of them. The time will say the truth.

The last comment you say: “People who have utterly shaved their head for yearsâ€
Do you know tonsure?. In my opinion this cultural practice is the one that develop really a common baldness (pattern hair loss) Do you know another way to make the same?

Armando

 

[Armando Jose]

Hi guys;
Concerning to the use of sebum and sebaceous gland in hair biology. Especially to who say that they are not important

Introduction:
Sebaceous glands are flask-shaped, lobulated structures made
of packed, differentiated epithelial cells that often have a
foamy appearance in sections because of the lipid-rich
droplets that fill their cytoplasm. Small cells located at the
periphery of the gland are the germinative cells that
constantly replace differentiating sebocytes. These glands
exhibit holocrine secretion which empties into the upper
region of the hair follicle canal.This secretory product
contains exfoliated and disintegrated sebocytes that form an
oily or greasy product known as sebum, which was
historically thought to only serve as a softening and waterproofing
agent for the skin. Current knowledge now indicates
that the functions of the sebaceous gland are more complex.
The sebum is now known to play important roles in the three dimensional
organization of skin surface lipids and the
integrity of the skin barrier (Stewart and Downing, 1991;
Pilgram et al., 2001; Fluhr et al., 2004), protect the skin
against oxidative stress (Thiele et al., 1999), and protect
keratinocytes against UVB irradiation (Marques et al., 2002).
Moreover, the sebum also exhibits innate antimicrobial
activity (Ge et al., 2003; Wille and Kydonieus, 2003; Georgel
et al., in press). Similarly, sebocytes express both pro- and
anti-inflammatory properties (Zouboulis et al., 1998; Bo¨hm
et al., 2002; Toyoda et al., 2002; Wro´bel et al., 2003), are
able to utilize cholesterol as a substrate for complete
steroidogenesis (Fritsch et al., 2001; Thiboutot et al., 2003),
present a regulatory program for neuropeptides (Zouboulis
et al., 2002), and selectively control the action of hormones
and xenobiotics on the skin (Akamatsu et al., 1992; Tsukada
et al., 2000). The importance of both the sebaceous gland
and sebum production in skin homeostasis is further
evidenced by the numerous skin disorders associated with
their aberrant activity, the most common of such disorders
being acne (Zouboulis et al., 2003; Zouboulis, 2004).
Normal development and function of the sebaceous gland
also appears to be very important for correct hair development
and cycling. The hair follicle is considered as a miniorgan
living in the context of the ‘‘pilo-sebaceous’’ unit,
which is composed of hair follicle, sebaceous gland, and
pilo-erector muscle (Montagna and Parakkal, 1974). Abnormal
sebaceous gland function within this context has been
clearly associated with hair loss in several animal models for
alopecia (Gates and Karasek, 1965; Gates et al., 1969;
Williams and Stenn, 1994; Stenn, 2001; Porter et al., 2002).

DISCUSSION
We observed the complete disruption of the sebaceous
glands, preceding hair loss, in our animal models of
chemotherapy-induced alopecia.


Full study at:
http://www.nature.com/jid/journal/v126/ ... 00175a.pdf


Others interesting documents:
Fritsch M, Orfanos CE, Zouboulis CC (2001) Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 116:793–800

Porter RM, Jahoda CA, Lunny DP, Henderson G, Ross J, McLean WH et al. (2002) Defolliculated (D-): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles. J Invest Dermatol 119:32–37

Stenn KS (2001) Insights from the asebia mouse: a molecular sebaceous gland defect leading to cicatricial alopecia. J Cutan Pathol 28:445–447

Thiele JJ, Weber SU, Packer L (1999) Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J Invest Dermatol 113:1006–1010


Best regards

Armando

 

[wookster]

:shock: :shock: :shock:

http://www.emedicine.com/derm/topic15.htm

Alopecia mucinosa, often referred to as follicular mucinosis, was first reported by Pinkus in 1957. The dermatologic eruptions consist of follicular papules and/or indurated plaques that demonstrate distinct histologic changes in the hair follicles that lead to hair loss. The accumulation of mucinous material in the damaged hair follicles and sebaceous glands creates an inflammatory condition and subsequent degenerative process. The face, the neck, and the scalp are the most frequently affected sites, although lesions may appear on any part of the body.

Pathophysiology
Alopecia mucinosa is a disease process defined histopathologically by mucin deposition in hair follicles and sebaceous glands, which undergo epithelial reticular degeneration. The exact pathogenesis is unknown, although the role of circulating immune complexes and cell-mediated immunity has been considered. The 3 clinical variants of the disease consist of a primary acute disorder of young persons, a primary chronic disorder of older persons, and a secondary disorder associated with benign or malignant disease.

 

[wookster]

Isn't it more like the immune system response to receptor sensitivity, and the resulting cascade of events after DHT exposure, is somewhat similar to an allergic reaction?

Except cells are killed off in male pattern baldness?

http://www.eurekalert.org/pub_releases/ ... 101002.php[/url]

Allergic to your DNA?

Scientists have discovered that the presence of undigested DNA left over from dead cells can elicit an immune response in the fruit fly Drosophila, prompting researchers to question whether an analogous autoimmune response could be triggered in humans.

[...]

"In mammals or humans, the activation of innate immunity causes the expression of various cytokines [cell signaling molecules]…that can induce inflammation or septic shock. If our results in Drosophila can be applied to mammalian systems, they suggest that DNA of the dying cells must be properly deposited. Otherwise, we will suffer from an immune response, like septic shock," explains Dr. Nagata. Further research is needed to determine if undigested apoptotic DNA can elicit an immune response in humans, but if so, this finding could open up a whole new list of possible culprits behind human autoimmune disease.

[/quote:cf34f]

:freaked: :freaked: :freaked:

http://www.timesonline.co.uk/tol/life_a ... 080680.ece

The allergies that are most likely to affect people have been becoming increasingly common over the past 30 years but there hasn’t been a corresponding allocation of funds to care for them either in hospital or general practice. The increase in the incidence of allergic conditions is real and cannot be accounted for by improved diagnosis or improved medical record-keeping.

[...]

As the boundaries of the spick and span, spotless lifestyle spreads across Europe, so does the allergy become more frequent. It is likely that the adverse effects of an over hygienic lifestyle exert their influence on children when they are still at the toddler stage of childhood or younger.

 

[wookster]

Interesting...

http://www.puritan.com/vf/healthnotes/H ... rn/BPH.htm

In a preliminary study, supplementation with a special aged garlic extract (Kastamonu Garlic) in the amount of 1 ml per 2.2 pounds of body weight per day for one month resulted in a 32% reduction in the size of the prostate gland and a significant improvement in urinary symptoms. It is not known whether other forms of garlic would have the same effect.

 

[wookster]

I think you'd be very happy, after a shed from months one and two, with topically applied peppermint oil mixed with purified water added to what you do now. It costs next to nothing, and it really does reduce beard hair, which we both know is androgenically driven.

Thanks for the tip irate: aranoid: irate:

http://www.ncbi.nlm.nih.gov/

Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism.


[...]

Mentha spicata Labiatae, known as spearmint and Mentha piperita Labiatae, known as peppermint can be used for various kinds of illnesses in herbal medicine and flavoring in industry. M. spicata Labiatae grows on the Anamas plateau of Yenithornarbademli town of Isparta, located in southwest part of Turkey. In this town, clinicians thought that consumption of tea steeped with M. spicata or M. piperita caused a diminished libido. Because antiandrogenic effects of spearmint and peppermint were found previously in rats, it was decided to observe the effect of this herbal tea on the androgen levels in hirsute women.Twenty-one female hirsute patients, 12 with polycystic ovary syndrome and 9 with idiopathic hirsutism were included to the study. They were took a cup of herbal tea which was steeped with M. spicata for 5 days twice a day in the follicular phase of their menstrual cycles. After treatment with spearmint teas, there was a significant decrease in free testosterone and increase in luteinizing hormone, follicle-stimulating hormone and estradiol. There were no significant decreases in total testosterone or dehydroepiandrostenedione sulphate levels.

Spearmint can be an alternative to antiandrogenic treatment for mild hirsutism. Further studies are needed to test the reliability of these results and the availability of spearmint as a drug for hirsutism.

http://en.wikipedia.org/wiki/Menthol

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.

http://www.poseidonsciences.com/anti-inflammatory.html

[quote:0a547]

SUMMARY

The findings described in this report indicate that menthol propyleneglycol carbonate (MPC), a GRAS food ingredient, is an effective nontoxic biochemical that may be used clinically as an anti-inflammatory and anti-androgenic agent.

[/quote:0a547]

http://www.mmtresearch.com/revivogen.htm

Revivogen Scalp Therapy Formula:

[...]

Ingredients:

Scalp Therapy Formula: SD Alcohol-40, Alpha Linolenic Acid, Gamma Linolenic Acid, Linoleic Acid, Oleic Acid, Palmitic Acid, Myristic Acid, Saw Palmetto Extract, Azelaic Acid, Pyridoxine Hydrochloride (Vitamin B6), Zinc Sulfate, Niacin (Vitamin B3), Tocopherol Acetate (Vitamin E), Menthol, Perfume.

 

[michael barry]

Wook,

.....In a preliminary study, supplementation with a special aged garlic extract (Kastamonu Garlic) in the amount of 1 ml per 2.2 pounds of body weight per day for one month resulted in a 32% reduction in the size of the prostate gland and a significant improvement in urinary symptoms. It is not known whether other forms of garlic would have the same effect.


You know maybe garlic inhibits alpha five reductase????Has it ever been studied for such?


Doctor noted a study a while back that had black tea reducing DHT in mice by 72%, which is roughly as much as finasteride does, while green tea increased it 164%. Possibly black tea inhibits alpha five reductase, but its not for certain unless it gets tested in humans, which we both know wont happen. Merk would absolutely throw a fit if naturals were tested for alpha five inhibition and so would glaxo-smith kline, it would represent a huge loss in money for them if some natural inhibited alpha five relatively well


I, for instance, utterly believe pine oil (beta sitosterol), peppermint oil, and probably green tea extract can sit on an androgen receptor and block them in the dermis, but we will never see FDA trials of such things.



On the DPPK negative growth factor.................................what do you want to bet one of those old essential oils like chamomille, horsetail, lavendar or whatever has a suppressive effect on it? I'd almost bet one would...............................

 

[michael barry]

Wook,

by the way..................menthol (like in revivogen) can be synthetic. I dont know if a synthetic would have the compounds in the peppermint oil. A little peppermint oil goes a long long way. I mix it at about a one to fifty ratio. It stings at one to thirty-three with purified water.

 

[wookster]

Wook,

.....In a preliminary study, supplementation with a special aged garlic extract (Kastamonu Garlic) in the amount of 1 ml per 2.2 pounds of body weight per day for one month resulted in a 32% reduction in the size of the prostate gland and a significant improvement in urinary symptoms. It is not known whether other forms of garlic would have the same effect.


You know maybe garlic inhibits alpha five reductase????Has it ever been studied for such?

http://www.time.com/time/covers/1101020121/garlic.html

Oh, that stinking rose! What makes garlic—and your breath—smell so bad is precisely what makes it so healthful. The odor factors are sulfur-based compounds known as allyl sulfides. Health gurus promote garlic as a cure-all, which it certainly is not, but many scientists agree that allyl sulfides and other phytochemicals in garlic may help protect the heart. Studies show that the sulfides can reduce cholesterol and may make the blood less sticky. Scientists are fairly confident that garlic also has antibacterial and antifungal powers. Preliminary reports even suggest that garlic may block the parasites that cause malaria. On perhaps less firm footing is the theory that allyl sulfides can stop tumor growth, a notion so far borne out only in the petri dish.

http://www.kyolic.com/html/products/log ... dients.htm

Aged Garlic Extract (AGE)


A variety of health related benefits of AGE have been widely demonstrated. Physicians from Memorial Sloan-Kettering Cancer Center at Cornell University recently found that S-allylmercaptocysteine (SAMC), a sulfur compound characteristic of AGE which is only produced during the aging of garlic, can break down dihyrotestosterone which accelerates abnormal cell growth. Both this peculiar organosulfur compound and AGE have also demonstrated antioxidant activity in studies. These effects in combination with AGE's ability to promote healthy circulation and immune function, make AGE essential for a quality a supplement aimed at providing nutritional support for healthy prostate function.

 

[wookster]

:freaked: :freaked: :freaked:

http://www.rehabpub.com/features/892000/2.asp

The Starling Hypothesis describes how fluids are exchanged between the blood capillaries, the tissue space, and the venous system.1 Ultrafiltration, reabsorption, and tissue pressure are the mechanisms that affect the lymphatic and circulatory systems. Ultrafiltration occurs in the arterial system. This process allows the passing of fluids, proteins, and nutrients from the arteries into the tissue spaces to provide nutrition to the body. After these nutrients have completed their tasks, they, along with fluids and small proteins, are reabsorbed into the venous system to return to the heart. Approximately 10% of the fluid traveling through the body is returned to the heart via the lymphatic system.1

The fluid entering this system is largely composed of dead cells, fatty tissues, large proteins, and noxious materials that will be filtered through the system’s lymph nodes before entering the heart. The portion that is unable to pass into the venous system remains in the interstitial spaces. This fluid causes pressure on the tissues under the skin, which forces the flaps in the capillaries of the lymphatic system to open, allowing the excess fluid to enter and be transported out of the limb or trunk area.

The lymph capillaries, which form an extensive plexus throughout the body, lie under the skin and are considered to be the start of the lymphatic system. The capillaries are made up of flat endothelial cells that overlap one another. The purpose of this overlapping is to allow absorption of fluids. Anchoring filaments attached to the capillaries assist in opening flaps when pressure from fluids increases.

Some of these filaments are attached in part to the underlayer of skin, which partially explains how the light touch of massage benefits in moving fluids.

The slight movement of the skin increases the amount of opening and closing of the flaps in the capillaries, allowing more fluid into the system. The fluid then enters the precollectors and is channeled to larger transport vessels. These vessels have many one-way passive valves that assure the direction of the fluid. Unlike the circulatory system, which has the heart to pump blood through it, the lymphatic system relies on intrinsic contractions of lymph angions.

The contractions of lymph angions are influenced by autonomous regulation through the sympathetic nervous system. Pain, external pressure, or increased pressure of fluids stretching the lymph vessels can contribute to increasing the number of lymph angion contractions. In a healthy lymph vessel, the lymph angion can contract 6 to 10 times per minute at rest and 60 to 100 times per minute with exercise, thereby moving more fluid through the lymphatic system and out of the limb or trunk.2

To further understand the importance of exercise when treating lymphedema, one needs to understand an impaired lymphatic system. Lymphedema is the result of a lymphatic system that is not adequately returning fluid at the needed rate to keep the affected limb or limbs clear of excess fluid. Therefore, fluid builds and becomes stagnated.

 

[Jkkezh]

I have a clogged lymph node on the right side of my head near my ear. It can be clearly felt.
Also my right temple is receded more then my left temple, but only by a bit......coincidence? :wink: I don't know


Btw: Thanks for all the reading material wook