Mitochondrial ROS Promote Epidermal Differentiation and Hair Growth

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Mitochondrial metabolism as a regulator of keratinocyte differentiation.

https://www.landesbioscience.com/journals/cellularlogistics/2013CELLULARLOG0003.pdf

Mitochondrial metabolism has traditionally been thought of as a
source of cellular energy in the form of
ATP. The recent renaissance in the study
of cellular metabolism, particularly in
the cancer field, has highlighted the fact
that mitochondria are also critical bio
-
synthetic and signaling hubs, making
these organelles key governors of cellu
-
lar outcomes.
1-5
Using the epidermis as
a model system, our recent study looked
into the role that mitochondrial metabo
-
lism and ROS production play in cellular
differentiation in vivo.
6
We showed that
conditional deletion of the mitochon
-
drial transcription factor, TFAM within
the basal cells of the epidermis results
in loss of mitochondrial ROS produc
-
tion and impairs epidermal differentia
-
tion and hair growth. We demonstrated
that mitochondrial ROS generation is
required for the propagation of Notch
and
b
-catenin signals which promote

epidermal differentiation and hair folli
-
cle development respectively. This study
bolsters accumulating evidence that oxi
-
dative mitochondrial metabolism plays
a causal role in cellular differentiation
programs. It also provides insights into
the role that mitochondrial oxidative
signaling plays in a cell type-dependent
manne