I've been using minoxidil and couvre for 10 years now. In the morning I put the minoxidil on, wait 15 minutes then apply Couvre to the entire head. At night, I just spray over the Couvre. Hopefully it absorbs through the Couvre. I have no choice as a pain to wash out the Couvre prior to bed. The Couvre does mess up your pillow when you do this, however.