Mineralocorticoid Antagonists Stimulate Hair Growth In Humans ex vivo.

[OtyMac]

Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo - PubMed

Whilst topical steroids represent one of the most frequently administered treatments for skin and hair diseases, predominantly based on their glucocorticoid receptor-mediated anti-inflammatory effects, the mineralocorticoid effects of topical steroids have received surprisingly little attention...

pubmed.ncbi.nlm.nih.gov

 

[OtyMac]

Since spironolactone doesn't work topically and you can't take it orally then what?

Well..

Frontiers | Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very...

www.frontiersin.org

One of the bioactive constituents found in dry seeds of burdock is arctigenin. It was recently found that arctigenin ameliorates endothelial dysfunction and reduces SBP in spontaneously hypertensive rats (SHRs; Liu Y. et al., 2015). The mechanism by which arctigenin seems to elicit its effects involves increased NO production as well as reduced levels of superoxide anion in thoracic aorta (Liu Y. et al., 2015). Interestingly, this bioactive ingredient was recently suggested to be a potential antihypertensive drug lead compound, owing to its newly discovered capacity as an antagonist of Mineralocorticoid receptor (Cheng et al., 2016). It is important to note here that although some report that this plant is popularly used for treatment of hypertension (Lee Y. J. et al., 2012), little evidence supports this notion; hence, we opted for including this plant among the herbs/plants that are less commonly used.