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I came across this study and I found it interesting because it talks about follicle units and how with MPHL vs FPHL more follicles stay attached to the Arrector Pili muscle with women than with men.
We have previously postulated that in FPHL, there is a hierarchy of androgen responsiveness within FU, with preferential miniaturization of secondary follicles.[5] Thus, the primary follicles may be those with the most intimate association with the AP, as well as the least susceptibility to miniaturization. The more susceptible secondary follicles may be those with less intimate contact with the APM.
In conclusion, we have identified loss of contact between the APM and the ORS (outer root sheath) in miniaturized hairs in MPHL and FPHL. In FPHL, the persisting terminal hair maintains contact with the APM.
In addition, we propose that in FPHL, where there is a hierarchy of androgen sensitivity within FUs, the persisting terminal hairs represent primary follicle within the FU and that the miniaturized follicles that lose contact with the AP represent the secondary follicles.
I guess this is what is biologically happening that is the difference with male vs female hair loss pattern?
Don't know why the difference.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500053/
We have previously postulated that in FPHL, there is a hierarchy of androgen responsiveness within FU, with preferential miniaturization of secondary follicles.[5] Thus, the primary follicles may be those with the most intimate association with the AP, as well as the least susceptibility to miniaturization. The more susceptible secondary follicles may be those with less intimate contact with the APM.
In conclusion, we have identified loss of contact between the APM and the ORS (outer root sheath) in miniaturized hairs in MPHL and FPHL. In FPHL, the persisting terminal hair maintains contact with the APM.
In addition, we propose that in FPHL, where there is a hierarchy of androgen sensitivity within FUs, the persisting terminal hairs represent primary follicle within the FU and that the miniaturized follicles that lose contact with the AP represent the secondary follicles.
I guess this is what is biologically happening that is the difference with male vs female hair loss pattern?
Don't know why the difference.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500053/
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