Male to Female and Exogenous Estrogens......

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The effect of oestrogen on cytokine and antioxidant levels in male to female transsexual patients

Whilst hormone replacement therapy (HRT) can be beneficial, it can be associated with deep venous thrombosis (DVT) and stroke. As male to female transsexuals take much higher doses of oestrogen than women on HRT, they provide a unique opportunity to study the long-term effects of oestrogen in a...

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Results​

The results showed that compared to the control group, patients on oestrogen had significantly raised levels of NO (32.1 ± 14.3 versus 20.3 ± 10.0, P < 0.05) and reduced levels of IL-6 (0.75 ± 0.6 versus 1.37 ± 0.7, P < 0.05) and SOD(don't mistake for SODase) (13.2 ± 3.0 versus 24.0 ± 10.0, P < 0.05). These changes were not accompanied by any significant change in plasma lipid levels.