Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells.

IDW2BB

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http://www.ncbi.nlm.nih.gov/pubmed/25536657

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells.
Castellana D1, Paus R2, Perez-Moreno M1.
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Abstract
Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.
 

Armando Jose

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"Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle"

Very interesting Thanks

 

drgs

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Can be activated with beta-glucan, which is used in some creams or nasal sprays
 

drgs

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Not sure if relevant, but interesting


Researcher Developing Tattoo Removal Cream

During tattooing, ink is injected into the skin, initiating an immune response, and cells called "macrophages" move into the area and "eat up" the ink. The macrophages carry some of the ink to the body's lymph nodes, but some that are filled with ink stay put, embedded in the skin. That's what makes the tattoo visible under the skin. Dalhousie Uiversity's Alec Falkenham is developing a topical cream that works by targeting the macrophages that have remained at the site of the tattoo. New macrophages move in to consume the previously pigment-filled macrophages and then migrate to the lymph nodes, eventually taking all the dye with them. "When comparing it to laser-based tattoo removal, in which you see the burns, the scarring, the blisters, in this case, we've designed a drug that doesn't really have much off-target effect," he said. "We're not targeting any of the normal skin cells, so you won't see a lot of inflammation. In fact, based on the process that we're actually using, we don't think there will be any inflammation at all and it would actually be anti-inflammatory."
http://www.cbc.ca/news/canada/nova-...udent-develops-tattoo-removal-cream-1.2955334
 
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