michael barry
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TOP > J-EAST > List of Journal Titles (J) > J Wood Sci(2001) > Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood. Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood.Accession number;01A0894142
Title;Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood.
Author;HIRANO Y(Fukuoka Industrial Technol., Fukuoka, Jpn) KONDO R(Kyushu Univ., Fukuoka, Jpn) SAKAI K(Kyushu Univ., Fukuoka, Jpn)
Journal Title;J Wood Sci
Journal Code:L3386A
ISSN:1435-0211
VOL.47;NO.4;PAGE.308-312(2001)
Figure&Table&Reference;FIG.3, TBL.1, REF.21
Pub. Country;Japan
Language;English
Abstract;5.ALPHA.-Reductase inhibitory activity of methanol extracts of the heartwood of 13 tropical wood species were examined. Strong 5.ALPHA.-reductase inhibitory activity was observed with Shorea species. From melapi(Shorea sp.), two known resveratrol trimers, vaticanol A and ampelopsin C, and two novel trimers were isolated as active compounds. The structures of the two novel resveratrol trimers were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, including 1H-1HCOSY, HMQC, and HMBC. The compounds were named melapinol A and melapinol B. There were no significant differences among the 5.ALPHA.-reductase inhibitory activities of the four resveratrol trimers, which were significantly stronger than those of .ALPHA.-linolenic acid and epigallocatechin gallate, known 5.ALPHA.-reductase inhibitors. (author abst.)
I think rat liver microsomal 5AR is type one. Apparently several wood oils inhibit type 1 alpha 5 reductase. My mind keeps going back to that cedarwood oil patent from Johsnon and Johnson. Cedarwood was the most effective agent in reducing sebum secretions in human skin that they found. I dont know about these things being able to inhibit human Type 2 alpha 5 reductase though, and the resveratrol in this experiment was apparently isolated from wood, not the kind that comes in a pill (LOL). This experiment probably just availed the rat liver cells to the substances. Its interesting info though to speculate upon.
Home Opinions Press Releases Link Categories J-EAST
TOP > J-EAST > List of Journal Titles (J) > J Wood Sci(2001) > Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood. Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood.Accession number;01A0894142
Title;Compounds inhibitory to rat liver 5.ALPHA.-reductase from tropical commercial wood species: resveratrol trimers from melapi(Shorea sp.) heartwood.
Author;HIRANO Y(Fukuoka Industrial Technol., Fukuoka, Jpn) KONDO R(Kyushu Univ., Fukuoka, Jpn) SAKAI K(Kyushu Univ., Fukuoka, Jpn)
Journal Title;J Wood Sci
Journal Code:L3386A
ISSN:1435-0211
VOL.47;NO.4;PAGE.308-312(2001)
Figure&Table&Reference;FIG.3, TBL.1, REF.21
Pub. Country;Japan
Language;English
Abstract;5.ALPHA.-Reductase inhibitory activity of methanol extracts of the heartwood of 13 tropical wood species were examined. Strong 5.ALPHA.-reductase inhibitory activity was observed with Shorea species. From melapi(Shorea sp.), two known resveratrol trimers, vaticanol A and ampelopsin C, and two novel trimers were isolated as active compounds. The structures of the two novel resveratrol trimers were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, including 1H-1HCOSY, HMQC, and HMBC. The compounds were named melapinol A and melapinol B. There were no significant differences among the 5.ALPHA.-reductase inhibitory activities of the four resveratrol trimers, which were significantly stronger than those of .ALPHA.-linolenic acid and epigallocatechin gallate, known 5.ALPHA.-reductase inhibitors. (author abst.)
I think rat liver microsomal 5AR is type one. Apparently several wood oils inhibit type 1 alpha 5 reductase. My mind keeps going back to that cedarwood oil patent from Johsnon and Johnson. Cedarwood was the most effective agent in reducing sebum secretions in human skin that they found. I dont know about these things being able to inhibit human Type 2 alpha 5 reductase though, and the resveratrol in this experiment was apparently isolated from wood, not the kind that comes in a pill (LOL). This experiment probably just availed the rat liver cells to the substances. Its interesting info though to speculate upon.
