You ask questions about lotion we know almost zero about. The italian users of home made lotion, that claim it has sides, but I saw: 1)no actual picture of laboratory test of their lotion,
2)no actual picture of progress with the lotion.
But Dr. Brotzu said, that it has no sides because of the liposomal delivery.
BTW:
To date, the evidenced primary mechanism of action of this antioxidant is to activate estrogen receptor-β (ER-β), which in turn enhances the expression of antioxidant enzymes and inhibits the expression of snail, a transcription factor that regulates keratinocyte cell proliferation and migration.88 A recent study showed that equol can influence expression of skin genes and proteins (i.e., increased collagen I and III, elastin, and TIMPs levels; decreased MMPs gene expression) using human monolayer fibroblast and three-dimensional organotypic cultures (Farid Menaa*, ... Jacques Tréton‡, in
Polyphenols in Human Health and Disease, 2014)
So equol activate estrogen receptor. If you deliver with liposomes directly to the cells in the head, then it will activate Es but won´t go systematical.