is it necessary to inhibt dht systemically?

[Gubter87]

X

 

[Bryan]

Is this true for all medications that inhibit DHT? Do they need to inhibit it systemically to have effect?

In my opinion, no. I think it's possible to make a very good and persuasive argument that circulating DHT has only a relatively minor effect on hair follicles. I think locally generated DHT (DHT produced by the hair follicles themselves) is much more important than serum DHT. If you can stop that local generation of DHT within hair follicles with an effective topical 5a-reductase inhibitor, I think you're well ahead of the game.

 

[amsch]

Is this true for all medications that inhibit DHT? Do they need to inhibit it systemically to have effect?

In my opinion, no. I think it's possible to make a very good and persuasive argument that circulating DHT has only a relatively minor effect on hair follicles. I think locally generated DHT (DHT produced by the hair follicles themselves) is much more important than serum DHT. If you can stop that local generation of DHT within hair follicles with an effective topical 5a-reductase inhibitor, I think you're well ahead of the game.

Yeah, but current topical anti-dht treatment results are pretty disappointing.

 

[believe]

I am sorry but even my grandfather knows that you can't expect good results without blocking DHT in your blood.
At least finasteride must be in your regimen list.

 

[Bryan]

I am sorry but even my grandfather knows that you can't expect good results without blocking DHT in your blood.
At least finasteride must be in your regimen list.

Sorry, I don't believe either one of those claims.

 

[abcdefg]

A topical could work wonders. The problem is there are pretty much no proven topicals that work like propecia, just tons of them that claim they do.

 

[Todd]

Do any of you know about people who have tried azelaic acid only?
I know Dr. Lee uses it along with minoxidil, but is it possible to get success with just azelaic acid only?


...because that would save us a fortune....

 

[believe]

You should be in a multifaceted treatment. It's not like using only spironolactone, azelaic acid, etc. If you are doing this, do not expect too much!

 

[Todd]

Do any of you know about people who have tried azelaic acid only?
I know Dr. Lee uses it along with minoxidil, but is it possible to get success with just azelaic acid only?


...because that would save us a fortune....

I doubt it. I used revivogen, which contatins azelaic acid, only for a while. I started to loose my hair again after about three months. Though this could be because of I also stopped using minoxidil - but the people at revivogen said that it would be able to keep the hairs gained from minoxidil (as if!)

dude, that's just plain wrong of them to say! They ought to know about minoxidil dependence!!

 

[floydian]

Do any of you know about people who have tried azelaic acid only?
I know Dr. Lee uses it along with minoxidil, but is it possible to get success with just azelaic acid only?


...because that would save us a fortune....

I use Lee's xandrox 5% with 5mg finasteride in the bottle(65 ml).

With it's wonder! No side effects, but my hair is growing like when I was with 0,5mg oral finasteride. Absolutely no sides! My little friend is O.K. like he was before the oral finasteride. :woot: