Interesting Hair Loss Treatment Study.

Funkymonk1

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I found this study. Wonder what people think.


"In a 2002 study published in The Journal of Dermatology, researchers compared the efficacies of different combinations of drugs used in the treatment of androgenetic alopecia.

This open, randomized clinical trial recruited 100 male patients suffering from this form of hair loss. They were divided into 4 groups corresponding to the drug(s) given to them.

  • Group I – 1 mg per day of oral finasteride (30 patients)
  • Group II – 1 mg/day oral finasteride + 2% topical minoxidil solution (36 patients)
  • Group III – 2% topical minoxidil solution (24 patients)
  • Group IV – 1 mg/day oral finasteride + 2% ketoconazole shampoo
The patients were placed on the drug combinations throughout the one-year duration of the study.

The results of this study showed all 4 groups of patients experienced significant hair growth. However, the best results were observed in patients in Group II followed by Group IV, I and III.

This study showed that ketoconazole shampoo ranks high amongst the drug used for treating androgenetic alopecia. Even though this is not its primary indication, it outperforms minoxidil solution and has an effectiveness comparable to finasteride.

This is all the more remarkable given that ketoconazole shampoo is a lot more affordable than minoxidil and finasteride.

The superiority of the combination of finasteride and ketoconazole was further confirmed by a 2004 study published in the journal, Medical Hypotheses. In this study, the researchers demonstrated that ketoconazole amplifies the inhibition of DHT (dihydrotestosterone, an androgen produced from tesoterone) that is begun by finasteride.

Therefore, the combination of oral finasteride and topical ketoconazole is the most effective way to treat androgenetic alopecia.

A 2002 study published in the International Journal of Cosmetic Science compared ketoconazole with a different set of drugs.

In this study, 1% solutions of ketoconazole, piroctone olamine and zinc pyrithione were the antidandruff shampoos randomly allocated to 150 men suffering from androgenetic alopecia accompanied with dandruff.

These topical solutions were administered 2 – 3 times per week for 6 months.

The researchers measured hair density at the crowns, hair shaft diameter, percentage of hair in anagen phase and the rate at which sebum is being secreted.

The results of the study showed that all 3 shampoos got rid of itching and dandruff quickly. In addition, while the 1% solutions were not strong enough to increase hair density, they did reduce hair shedding (ketoconazole > piroctone olamine > zinc pyrithione).

In addition, ketoconazole and piroctone olamine shampoos increased the thickness of hair shafts while reducing the rate at which sebum is pushed to the surface of the scalp.

This study further proves that ketoconazole even at 1% concentration can provide some benefits for people experiencing hair loss. At this concentration, ketoconazole can stop further hair loss while marshalling some of the factors that can promote the growth of new hair."
 
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