If This Is True: Breaking News On Samumed

Pavi

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http://www.beIgraviacentre.com/blog/stem-cell-treatment-may-provide-male-hair-loss-cure/

Could be HUGE. SM entering phase III??
 

Dolph

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This isn't true. Samumed is doing another phase II, which hasn't even started yet (https://clinicaltrials.gov/ct2/results?term=SM04554&Search=Search).

Per Business Insider in April: (http://www.businessinsider.com/samumed-wants-to-regenerate-hair-bone-cartilage-2017-3)

In the second study, those on the .25% had slightly more follicle growth than the .15% group. To get an even better picture of how the treatments work long term, Samumed is setting up another phase-two trial that will include both doses to figure out which one is the best to use in a phase-thee study that could set the treatment up for approval with the FDA.
 

That Guy

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If I was a betting man, the smart bet would be that this doesn't even get released.

A 10% increase is not even as good as what conventional treatments can deliver and the fact that the lower dose gave the greater results means it's quite likely there's nothing you can do to squeeze any better results out of it then 10% and we don't even know that these results are permanent (probably not). Perhaps by some weird-*** voodoo, using it for extended periods of time would see continuous results, but I'm not holding my breath.

If they're doing another Phase 2, it's because they know the ship is sinking and this is the last-ditch effort to prove it can really make a difference. Otherwise, it's not worth bringing a treatment to market that can't compete with current products.

but hey, it's just more waste-of-time topicals for hairloss failing hard as usual.

That 3 month result gets me hard

That is a minoxidil patient
 
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Dolph

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If I was a betting man, the smart bet would be that this doesn't even get released
I am a betting man, and if you were too, I would take that bet. Samumed is currently valued at $12bn after raising over $300m. If you were Samumed, you'd take your time bringing things to market, too, with that much at stake. They can't start shelving their pilot products and expect investor confidence to remain.
 

Xenithrising

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If I was a betting man, the smart bet would be that this doesn't even get released.

A 10% increase is not even as good as what conventional treatments can deliver and the fact that the lower dose gave the greater results means it's quite likely there's nothing you can do to squeeze any better results out of it then 10% and we don't even know that these results are permanent (probably not). Perhaps by some weird-*** voodoo, using it for extended periods of time would see continuous results, but I'm not holding my breath.

If they're doing another Phase 2, it's because they know the ship is sinking and this is the last-ditch effort to prove it can really make a difference. Otherwise, it's not worth bringing a treatment to market that can't compete with current products.

but hey, it's just more waste-of-time topicals for hairloss failing hard as usual.



That is a minoxidil patient
I just skimmed. Wish my Minoxidil results were that good.
 

That Guy

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They can't start shelving their pilot products and expect investor confidence to remain.

Confidence won't remain if Phase II 2 doesn't yield results of godlike proportions.

You'll see more people pulling out than at a catholic orgy.

I would assume...
 

zaman

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10% is fantastic if it includes the hairline.

I would not scoff at that seeing as minoxidil and finasteride gave me exactly 0% regrowth
 

That Guy

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10% is fantastic if it includes the hairline.

I would not scoff at that seeing as minoxidil and finasteride gave me exactly 0% regrowth

I would scoff at that because people who do respond to minoxidil and finasteride can expect to see those same results or better.

10% regrowth is only going to matter if it is a guaranteed, long-lasting or preferably permanent result. Otherwise, it's no competition for current treatments.

Also, Shiseido and Follica should be out within the next 3 years at the latest. We know the former stabilizes hairloss, seemingly indefinitely as predicted; the latter is rooted (ha) in wounding neogenesis (which we know grows hair), Puretech is making the move to the pivotal trial and they've been rallying dermatologists while keeping the public eye away from it, so it's a safe bet that whatever they have will offer superior results to conventional treatments and we can expect data on it soon, according to a recent article.

There's also the fact that a Japanese dude may very well perform successful hair cloning on humans in 2019 and if the cards are played right, rich bald dudes will be throwing money at it like a stripper the following year.

Despite their current value, I certainly wouldn't throw any money at samumed. At least, not based on their hairloss product.
 

Medina

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I would scoff at that because people who do respond to minoxidil and finasteride can expect to see those same results or better.

10% regrowth is only going to matter if it is a guaranteed, long-lasting or preferably permanent result. Otherwise, it's no competition for current treatments.

Also, Shiseido and Follica should be out within the next 3 years at the latest. We know the former stabilizes hairloss, seemingly indefinitely as predicted; the latter is rooted (ha) in wounding neogenesis (which we know grows hair), Puretech is making the move to the pivotal trial and they've been rallying dermatologists while keeping the public eye away from it, so it's a safe bet that whatever they have will offer superior results to conventional treatments and we can expect data on it soon, according to a recent article.

There's also the fact that a Japanese dude may very well perform successful hair cloning on humans in 2019 and if the cards are played right, rich bald dudes will be throwing money at it like a stripper the following year.

Despite their current value, I certainly wouldn't throw any money at samumed. At least, not based on their hairloss product.

But combined with OTHER treatments it might be a Godsend. I don't think we'll see a one-route cure for baldness in the next 20 years. But if we can tackle do the Wnt angle, the prostoglandin angle, the androgen angle, the bloodflow angle (or whatever the hell mino is supposed to do) etc etc... we might just stand a chance.
 

resu

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But combined with OTHER treatments it might be a Godsend. I don't think we'll see a one-route cure for baldness in the next 20 years. But if we can tackle do the Wnt angle, the prostoglandin angle, the androgen angle, the bloodflow angle (or whatever the hell mino is supposed to do) etc etc... we might just stand a chance.

Might be too little too late, Breezula is an anti-antrogen, that's always useful but will also only come in 2021 at best. Everything is long away.
 

stachu

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"If we combine then might be godsent " yeah if we combine with minoxidil alfatradiol finasteride andenosine ketoconizal ru dutasteride magic "italian lotion" dermaroller then some improvements might occur. Just lol. We need some thing effective as finasteride or minoxidil. Besides, everything need to be put in not effective category.
 

Afro_Vacancy

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"If we combine then might be godsent " yeah if we combine with minoxidil alfatradiol finasteride andenosine ketoconizal ru dutasteride magic "italian lotion" dermaroller then some improvements might occur. Just lol. We need some thing effective as finasteride or minoxidil. Besides, everything need to be put in not effective category.

I'm fine combining treatments that have independent mechanisms and whose efficacy is demonstrated in robust trials.

Just FYI using five different anti androgens is probably overkill.
 

Medina

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"We need some thing effective as finasteride or minoxidil.

And I need a bigger dick but sometimes you just gotta role with the punches.

Look, Gentlemen. We have a very old saying here in England...."Beggars can't be choosers". If there's a product coming out that may help us even a little bit, or that can be added to a regime, then that's good news to me.
 

Afro_Vacancy

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Another factor is that Samumed has enough capital to lobby the FDA.
 

stachu

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Well, if you're fine mixing. Then Okay. Actually you can spend 1000$ every month for regimen and buy all of indegrients "proven" to be atleast a bit effective and put it on bald head or eat tons of capsules and you will slow down male pattern baldness - For sure and I don't mind how many times per day you need to remember about all stuff needed to be aplicated... / But for Me, I would choose an option where you pick just one tablet or one lotion application per day or 2x. And ill don't think about if its gonna loose effectiveness, about sides, about FDA etc etc or about post syndromers killing yourselves by jumping from 10th floor or about turbo masturbators experiencing permanent ED after one pill. I am Currently using 4 things. Its still a lot for me. Since I cant sometimes be systematic to put minoxidil twice daily and i will not say how many days I skip finasteride dose.
 

Afro_Vacancy

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I do minoxidil mixed with RU once a day. I need to mix them every four or five months. I also apply either alfatradiol or stemoxydyine straight after, all in the morning. That I'll need to buy more of in about three months.
 

Dolph

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I would scoff at that because people who do respond to minoxidil and finasteride can expect to see those same results or better.

10% regrowth is only going to matter if it is a guaranteed, long-lasting or preferably permanent result. Otherwise, it's no competition for current treatments.

Also, Shiseido and Follica should be out within the next 3 years at the latest.

I laughed out loud when I read you have more faith in Follica than Samumed. Follica is the next Pilox. Just use some minoxidil and a dermaroller, you'll save time and money.

Even if Samumed results aren't great, it might work synergistically with other available treatments. Who on the Big 3 wouldn't start using the Big 4 instead, if Samumed gives them an extra 10%?

In any case, the reality is that we just don't know, because there isn't long term data yet. But I'm guessing they beat Shiseido to US market. Certainly those of us who are more clued in and following this stuff will fly to Japan if Shiseido yields results, but Samumed is best positioned to bring something to the US market first. If Samumed works even a little bit, I'm sure they'll be happy to claim the title of first pharmaceutical in 20 years to get something approved by the FDA for hair loss. And they're the ones with the capital to actually complete the gauntlet of FDA approval and manufacturing. We'll see!

Only thing that worries me about Samumed is how quiet they've been -- why hasn't Phase IIB started yet?
 
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