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Seeing as it decreases DHT by like 99%.
Just don't see how you can continue to lose hair on the stuff as long as you're on it.
Just don't see how you can continue to lose hair on the stuff as long as you're on it.
If Dutasteride Works, Shouldn't It Work For Life?
- Thread starter Gotigers85
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hanginginthewire
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DHT isn't necessarily the only trigger for hair loss though. We still don't know all the causes of it.
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Before you go concluding that there is some hidden mysterious 'other' cause for male pattern baldness, you need to first make sure that you have actually removed all DHT.
Dutasteride at the usual 0.5 mg doesn't doesn't remove "like 99% of DHT", especially not where it actually matters - in the scalp, not even close.
I don't know how many times I've posted this study in the past month but it's really starting to become a meme at this point:
http://www.regrowth.com/remedies/phase-ii-fda-hair-loss-study-results-for-avodart-dutasteride/
Dutasteride at the usual 0.5 mg doesn't doesn't remove "like 99% of DHT", especially not where it actually matters - in the scalp, not even close.
I don't know how many times I've posted this study in the past month but it's really starting to become a meme at this point:
http://www.regrowth.com/remedies/phase-ii-fda-hair-loss-study-results-for-avodart-dutasteride/
hanginginthewire
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I appreciate your passion and I hope you're right, but don't you think if duta truly HALTED 90 percent of men's hair loss that the word would get out? Do a quick Google search and you will see post after post from people reporting their continuing hair loss.
Edit - Nevermind, I see you are making a different point about even Duta not removing all scalp dht. But dont even transgenders often still suffer from male pattern baldness when they have even had genital surgery?
Edit - Nevermind, I see you are making a different point about even Duta not removing all scalp dht. But dont even transgenders often still suffer from male pattern baldness when they have even had genital surgery?
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I could be wrong, but I was under the impression that when scalp DHT is measured, most of it has come from type 1 5 alpha reductase, which plays only a small role in hair loss as it is not found in high amounts at the hair follicle, where type 2 5 alpha reductase is predominant. Surely dutasteride 0.5 mg does remove most DHT where it matters - at the hair follicle.
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The theories are completely irrelevant at this point.
One only needs to look at the superior hair counts of the 2.5 mg dose and the conclusion of even the studies' authors that inhibition of type I is just as important because the 2.5 mg dose inhibits way more scalp DHT while having only slightly higher inhibiton of serum DHT than the 0.5 mg dose. That points to the importance of scalp DHT and type I 5-AR in improving the hair loss outcome just as well.
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I don't think I've seen a post online with pictures of someone who's lost considerable ground on duta.
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Just duta .5 ED
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"if dutasteride works, shouldn't it work for life" - maybe? only if you're lucky.
the fact is, NO one, not even the leading authorities in this field can answer this question. We have all searched high and low for some comfort in this manner... but there is very little. I often see people on here and other forums that have tried dutasteride religiously for over a year and and lost ground.
that being said - it is the "best" option in hair loss treatments imo.
the fact is, NO one, not even the leading authorities in this field can answer this question. We have all searched high and low for some comfort in this manner... but there is very little. I often see people on here and other forums that have tried dutasteride religiously for over a year and and lost ground.
that being said - it is the "best" option in hair loss treatments imo.
Scalp DHT measurements were also assessed for both DHT and Testosterone. Scalp DHT was decreased 27% for 0.05mg Dutasteride, similarly for Finasteride (38%) and Dutasteride 0.1mg (37%), 54% for 0.5mg, and 82% for 2.5mg Dutasteride. Rittmaster concluded that these results show that most of the DHT in the scalp comes from type 1 5-alpha reductase.
So 1MG of finas blocks only 38% of scalp DHT? Also there is a significant difference between .5 and 2.5 of Dutas. I wonder what even higher dosage would do.
So 1MG of finas blocks only 38% of scalp DHT? Also there is a significant difference between .5 and 2.5 of Dutas. I wonder what even higher dosage would do.
cyrusthegreat@hotmail.com
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Effect of dutasteride 0.5 mg/d in men with androgenetic alopecia recalcitrant to finasteride.
https://www.ncbi.nlm.nih.gov/pubmed/24898559
WOOO! You da bomb! Every little bit of hope helps at this point lol
I know it's only a small sample, but that means that Dutasteride was successfull in stopping hair loss in 100% of patients that didn't respond to finasteride.
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In the attached study, (which I also posted five times already), is mentioned the probability of you to actually loose ground on finasteride.
If you sum up all the columns that show actual worsening, you get something around then percent.
So while 30-50 % don't improve on finasteride, only 10% get much worse over ten years.
Add the duta study and you get pretty good odds for us.
However I think treatment is about balancing the hormones. Many threads are about how dutasteride wrecked someone's hair.
I think that is because some people respond too much, and ultimately loose hair because of high estrogen, upregulation ect.
I would love to find more studies, to get some actual manual together: what works for which person.
If you sum up all the columns that show actual worsening, you get something around then percent.
So while 30-50 % don't improve on finasteride, only 10% get much worse over ten years.
Add the duta study and you get pretty good odds for us.
However I think treatment is about balancing the hormones. Many threads are about how dutasteride wrecked someone's hair.
I think that is because some people respond too much, and ultimately loose hair because of high estrogen, upregulation ect.
I would love to find more studies, to get some actual manual together: what works for which person.