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Identification of de novo Androgenesis in the Scalp of Men with Androgenetic Alopecia.
http://proj.ncku.edu.tw/research/articles/e/20080418/3.html
We hypothesized that de novo synthesizing pathway may play important roles in causing local overproduction of androgen in Androgenetic Alopecia patients. By use of a quantitative, competitive reverse transcription-polymerase chain reaction method (Figure 2), the current paper demonstrated and quantified the expression of StAR, P450scc, P450c17 and type I 3β-HSD in the bald scalp of men with Androgenetic Alopecia. The amounts of mRNA expressed by the scalp are most abundant for StAR, followed by 3β-HSD, and much less for P450scc and P450c17. Besides, significantly higher levels of StAR and 3β-HSD were demonstrated in the bald parieto-frontal scalp as compared to the hairy occipital scalp (Figure 3). No regional difference existed regarding P450scc and P450c17. Immunohistochemistry also showed strong expression of StAR in the basal layer of sebaceous glands (Figure 4a), epidermal keratinocytes (Figure 4b) and outer root sheath of hair follicles (Figure 4c). This is the very first report that demonstrates the presence of all steroidogenic enzymes in hair follicle and provides evidence to support the notion that de novo biosynthesis of androgen in local region is feasible.
[h=2]Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3
-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia[/h]
http://www.nature.com/jid/journal/v126/n10/full/5700442a.html
http://proj.ncku.edu.tw/research/articles/e/20080418/3.html
We hypothesized that de novo synthesizing pathway may play important roles in causing local overproduction of androgen in Androgenetic Alopecia patients. By use of a quantitative, competitive reverse transcription-polymerase chain reaction method (Figure 2), the current paper demonstrated and quantified the expression of StAR, P450scc, P450c17 and type I 3β-HSD in the bald scalp of men with Androgenetic Alopecia. The amounts of mRNA expressed by the scalp are most abundant for StAR, followed by 3β-HSD, and much less for P450scc and P450c17. Besides, significantly higher levels of StAR and 3β-HSD were demonstrated in the bald parieto-frontal scalp as compared to the hairy occipital scalp (Figure 3). No regional difference existed regarding P450scc and P450c17. Immunohistochemistry also showed strong expression of StAR in the basal layer of sebaceous glands (Figure 4a), epidermal keratinocytes (Figure 4b) and outer root sheath of hair follicles (Figure 4c). This is the very first report that demonstrates the presence of all steroidogenic enzymes in hair follicle and provides evidence to support the notion that de novo biosynthesis of androgen in local region is feasible.
[h=2]Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3
http://www.nature.com/jid/journal/v126/n10/full/5700442a.html
