I am SO UPSET!

[guy83]

OK so I ordered from this drug store online. 111drugstore.com.

The post man dilvered it on Friday, when I wasnt there. I had to pick it up on Saturday. Except I didnt know if he was actually gonna try to deliver it again or I should pick it up. I waited for him, but by the time I went to the office where the package was it was closed.

I cant get into it untill Monday, which would have been OK except that I am going to California for a while. I called and the good thing they would hold the package untill I get back but they dont have access to the building that has the package right now..etc

Im gonna run out of Propecia in 10 days. Im gonna try to buy some on Monday and have it shipped to the address that Im gonna be staying at. Where can I get the fastest Proscar? I just want like 30 days quantity.

 

[asolof]

If you have a prescription you could go to any pharmacy. If not, you could also divide your 1mg propecia pills into thirds (0.33mg) to stretch out the supply for 30 days. Or you could take one 1mg propecia pill every 3rd day. Not ideal, but better than going 20 days without any.

 

[Guest]

I agree with the monkey, stetch what you have out for 30 days .33mg a day is almost as effective as 1mg.

Ty

 

[Deaner]

But what happens if it doesn't work out for him in the end... he'll always wonder if it was because he took 0.33mg for that time period instead of 1mg... it'll be total chaos.

 

[blue]

finasteride stays in your system for a while just like any other oral medicine..just make sure to get that sh*t as soon as possible

 

[BadHairDecade]

actually finasteride has a half life of 6-8 hours so it doesn't stay in your system that long. I agree with cutting it up if you can't get your hands on any. There have been studies that showed .22mg (I think) to be just as effective as 1mg.

 

[ACT10Npack]

Try to get a friend to get the package and ship it where your leaving now. I never heard finasteride has an halflife of 6 to 8 hours. Which it does not make any sense because you would have to take ti 3 times a day, if that was true.

 

[BadHairDecade]

6-8 hours is 100% true...It's been stated several times already. GO to page three of this PDF provided by Merck and look at the chart.
http://www.merck.com/product/usa/pi_cir ... car_pi.pdf

It's also mentioed on page 2 of this PDF from Merck
http://www.merck.com/product/usa/pi_cir ... cia_pi.pdf

BTW why do you think you'd have to take it three times a day?

BHD

 

[Deaner]

Half-life doesn't mean it's gone after 6-8 hours, it simply means half of it's still active in your body after that amount of time, s'all.

 

[Guest]

But what happens if it doesn't work out for him in the end... he'll always wonder if it was because he took 0.33mg for that time period instead of 1mg... it'll be total chaos.

Deaner are you saying given the choice of.......

1.) going for 20 days without Finasteride

2.) reducing to a dose that has extensive trial data showing it to be almost as effective as a 1mg dose (this information is from Mercks own trails)

.....that you would advise the first option ?

why would this cause 'total chaos' ?

Don't you think that if it doesn't work out for him in the end... he'll always wonder if it was because he missed 20 doses in straight succession ?

We already trust Merck's science (or we would not be taking Finasteride) so it is bad logic to cherry pick through their data armed only with fear.

 

[asolof]

Yes, the serum half life is short, but the package insert also says that the Type II alpha-reductase enzyme in the scalp and prostate turns over every 30 days. Presumably it is the enzyme inhibition in the tissues which is long lasting, not the serum half life.

 

[Deaner]

I was just kidding tynan :wink:

 

[Guest]

I was just kidding tynan :wink:

 

[BadHairDecade]

I was just kidding tynan :wink:

I didn't get the joke either.... If you we're going for a comical approach it was poorly executed. Try smily's next time or maybe something that's actually funny :lol:

 

[Guest]

I was just kidding tynan :wink:

I didn't get the joke either.... If you we're going for a comical approach it was poorly executed. Try smily's next time or maybe something that's actually funny :lol:

ooohhhh.... b**ch slap!

 

[Deaner]

wow, you guys are way too hardcore for me :roll:

 

[Bryan]

Yes, the serum half life is short, but the package insert also says that the Type II alpha-reductase enzyme in the scalp and prostate turns over every 30 days. Presumably it is the enzyme inhibition in the tissues which is long lasting, not the serum half life.

Exactly, although I have a problem with the exact figure you quoted above.

Finasteride has a fairly short half-life of only a few hours in the blood, but the important thing to understand is that the 5a-reductase enzyme ITSELF is produced only very slowly! Both finasteride and dutasteride are considered to be irreversible inhibitors of the type 2 enzyme. In other words, once a molecule of either one of those drugs binds with a molecule of the enzyme, that enzyme molecule is essentially DESTROYED. It will never produce DHT again! However, new "fresh" molecules are constantly being produced, only at a pretty slow rate. According to some recent dutasteride studies, the "half-life" regeneration rate for the type 2 enzyme is 80 hours. For the type 1 enzyme, it's 45 hours (that's one reason why it's harder to inhibit the type 1 enzyme than the type 2 enzyme: the stuff is always being produced faster!).

Bryan

 

[asolof]

Bryan,

I got my numbers from the package insert
http://www.propecia.com/propecia/shared ... nts/pi.pdf
under the section "Clinical Pharmacology".

They didn't use the term "half-life". They used the term "Turnover" and said

" The turnover for the enzyme complex is slow (t 1/2 approximately 30 days for the Type II enzyme complex and 14 days for the Type I complex."

I took this to mean 1/2 of the Type II complex (ie. Type II enzyme combined with and inactivated by finasteride) would be replaced in 30 days by new, active, uncomplexed enzyme. Maybe I am misunderstanding this. Where did you get the numbers you posted?