- Reaction score
- 194
Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy.
Hydroxytyrosol , a primary phenolic antioxidant in olive oil, can afford protection from oxidative stress (OS) in different cells, including skin cells. In particular, it regulates several inflammation‐associated processes as well as in improving the antioxidant defense system. However, there is no information about hair transplant used in the treatment of hair loss. This work aimed at exploring the potential protective actions of hair transplant against OS in rat dermal papilla cells. After treatment, the related expression of protein and messenger RNA were detected using morphological and molecular analyses. The results showed that hair transplant significantly reduced intracellular reactive oxygen species level, apoptotic markers and inflammation induced by OS and enhanced cell survival by regulating autophagy. Furthermore, hair transplant enhanced the secretion of hair growth factors in the anti‐inflammation process. These results suggest that hair transplant has a significant protective ability against OS and encourage the use of this biological ingredient as a possible tool to prevent alopecia.
https://www.ncbi.nlm.nih.gov/pubmed/31332898
Hydroxytyrosol , a primary phenolic antioxidant in olive oil, can afford protection from oxidative stress (OS) in different cells, including skin cells. In particular, it regulates several inflammation‐associated processes as well as in improving the antioxidant defense system. However, there is no information about hair transplant used in the treatment of hair loss. This work aimed at exploring the potential protective actions of hair transplant against OS in rat dermal papilla cells. After treatment, the related expression of protein and messenger RNA were detected using morphological and molecular analyses. The results showed that hair transplant significantly reduced intracellular reactive oxygen species level, apoptotic markers and inflammation induced by OS and enhanced cell survival by regulating autophagy. Furthermore, hair transplant enhanced the secretion of hair growth factors in the anti‐inflammation process. These results suggest that hair transplant has a significant protective ability against OS and encourage the use of this biological ingredient as a possible tool to prevent alopecia.
https://www.ncbi.nlm.nih.gov/pubmed/31332898