How do i sign up?

[SSM23]

Saw this on the newsletter but can't see any more detail or where i an sign up.

any ideas?


Bristol Myers/Squibb is conducting a nationwide study to determine the effectiveness and safety of an investigational medication for male pattern hair loss. They are recruiting patients for this trial in several cities across the country...

In this study, the medication will be applied to the surface of the scalp for a duration of 30 weeks with monthly visits to a dermatologist. It is being conducted from several states across the nation, and they would like volunteers who qualify to fill out the form below regarding being a part of the study. This compound is chemically similar to Minoxidil (Rogaine) in that it works by opening ion channels within cells. However, the compound being tested has been shown to be 1000 times stronger than Minoxidil as a channel opener / potential hair growth stimulant.

If you are a Male between the ages of 18 and 40 and fit the criteria listed on the page below, we welcome you to fill out the form at the bottom of the page, and participate in the study. We would also ask that those who do not qualify for the study according to the list of requirements, not participate in this study. It is important to keep studies like this accurate and useful, or it will be to the detriment of hair loss sufferers everywhere. Thank you for your understanding.

 

[Bismarck]

I bet this is / was CPA !!!

 

[misterium]

yeah and what's CPA ?

 

[Bismarck]

N 6 - cyclopentyladenosine

 

[Fallout Boy]

I bet this is / was CPA !!!

are you saying it like its a bad thing??

 

[Bismarck]

CPA works in about the same way minoxidil does. It's a potassium channel opener but it does so about 1000 times better so I thought they used CPA in their trial.
Actually some of the German forum ordered CPA and are using it at this time. Simple Adenosine (as it is found in adenogen) is the "weaker alternative" to CPA.

 

[The Gardener]

Bis, kind of an off-topic question here, but, I know you are posting from Germany and I must ask... are you German, or are you an English-speaking ex-pat living in Germany? I ask you this because your English is impeccable. You speak as good or better than a lot of native speakers here on this MB. I was just wondering.

 

[Bryan]

I ask you this because your English is impeccable.

Most of the time it's impeccable, but sometimes it's peccable!

Bryan

 

[Bismarck]

Bis, kind of an off-topic question here, but, I know you are posting from Germany and I must ask... are you German, or are you an English-speaking ex-pat living in Germany? I ask you this because your English is impeccable. You speak as good or better than a lot of native speakers here on this MB. I was just wondering.

Born and living in Germany. I had exactly 5 years English at school but the 5 years Latin did the trick for learning languages, in my opinion. And yes, I hated english lessons, I hated my english teachers, I hated school.

 

[The Gardener]

Bis, 5 years of English, and 5 years of LATIN on top of that?! No wonder! Anyone who can see through that program is naturally skilled in linguistics, and CRAZY too! Are languages somewhat of a hobby for you?

Then again, I can understand. English is half Latin, half Germanic. If you understand the root tongues of the two, I can see how English might be more palatable for you. Nevertheless, I appreciate your grasp of English, and your contributions here.

 

[Bismarck]

Bis, 5 years of English, and 5 years of LATIN on top of that?! No wonder! Anyone who can see through that program is naturally skilled in linguistics, and CRAZY too! Are languages somewhat of a hobby for you?

Not really. I became more and more interested in natural sciences and math so today programming languages are my "hobby".

 

[Red Rose]

http://www.lipoxidil.com/

I believe the product you guys are referring to is "t-Adenosine" solution available at lipoxidil.com.

 

[Bismarck]

http://www.lipoxidil.com/

I believe the product you guys are referring to is "t-Adenosine" solution available at lipoxidil.com.

No. That's the substance in Adenogen. It's not CPA.

 

[Red Rose]

A Randomized Trial of Adenosine In Androgenetic Alopecia.

Watanabe Dermatological Clinic, Tokyo, Japan. etc. al. June, 2004.

Objective: Adenosine upregulates the expression of fibroblast growth factor 7 (FGF7) and vascular endothelial growth factor (VEGF) on cultured dermal papilla cells via adenosine receptors. We therefore speculated that adenosine stimulates growth of hair fiber due to the action of FGF7 and VEGF for epithelial cells in hair follicles. In this study, we performed a clincial trial to investigate the efficacy and safety of adenosine in hair loss associated with androgenetic alopecia (Androgenetic Alopecia).

Methods: A hundred and four volunteers with Androgenetic Alopecia were registered in a randomized double-blind trial that used an adenosine (0.75%) topical lotion or niacin amide (0.1%) topical lotion twice daily for 6 months. Efficacy was evaluated by investigator assessments of change in global scalp coverage, change in the ratio of vellus-like (under 40 um in diameter) and thick hairs (not less than 60 um or 80 um in diameter), and hair density, in vertex.

Results: Fifty-one of 52 adenosine-treated subjects and 50 of 52 niacin amide-treated subjects completed the 6-month study. For global improvement, adenosine was significantly superior to niacin amide. Treatment with either lotion resulted in a significantly decreased ratio of vellus-like hair and also significantly increased the ratio of thick hair, but did not change the hair density. Regarding the increase in the ratio of thick hair, adenosine was significantly superior to niacin amide. Adverse effects were not found.

Conclusion: In men with Androgenetic Alopecia, adenosine increased hair growth and thickened vellus-like hair without side effects. It would appear that the efficacy of hair growth results from the effects of FGF7 and VEGF which are stimulated by activation of adenosine receptors on dermal papilla cells.

........................................................

J Invest Dermatol. 2001 Dec;117(6):1594-600.

Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.

The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal papilla cells. The mechanism of production of vascular endothelial growth factor remains unclear, however. We hypothesize that adenosine serves as a mediator of vascular endothelial growth factor production. Minoxidil-induced increases in levels of intracellular Ca(2+) and vascular endothelial growth factor production in cultured dermal papilla cells were found to be inhibited by 8-sulfophenyl theophylline, a specific antagonist for adenosine receptors, suggesting that dermal papilla cells possess adenosine receptors and sulfonylurea receptors, the latter of which is a well-known target receptor for adenosine-triphosphate-sensitive potassium channel openers. The expression of sulfonylurea receptor 2B and of the adenosine A1, A2A, and A2B receptors was detected in dermal papilla cells by means of reverse transcription polymerase chain reaction analysis. In order to determine which of the adenosine receptor subtypes contribute to minoxidil-induced hair growth, the effects of subtype-specific antagonists for adenosine receptors were investigated. Significant inhibition in increase in intracellular calcium level by minoxidil or adenosine was observed as the result of pretreatment with 8-cyclopentyl-1,3-dipropylxanthine, an antagonist for adenosine A1 receptor, but not by 3,7-dimethyl-1-propargyl-xanthine, an antagonist for adenosine A2 receptor, whereas vascular endothelial growth factor production was blocked by both adenosine A1 and A2 receptor antagonists. These results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosine.

PMID: 11886528 [PubMed - indexed for MEDLINE]

..................................................

Cyclopentyladenosine improves cell proliferation, wound healing, and hair
growth.
Sun LL, Xu LL, Nielsen TB, Rhee P, Burris D.

Department of Surgery, Uniformed Services University of the Health Sciences,
Bethesda, Maryland 20852, USA. lsun@usuhs.mil

BACKGROUND: N(6)-Cyclopentyladenosine (CPA), a structural analog of adenosine, is a vasodilator with extensive pharmacological effects. However, little is known about the effect of CPA on wound healing and hair growth.

METHODS: Cellular responses to CPA were measured in vitro by tetrazolium dye reduction and in vivo by bromodeoxyuridine (BrdU) uptake. The effect of CPA on healing of incisional and excisional wounds on the dorsum of diabetic (db/db, n = 94) and nondiabetic (db/+, n = 20) mice and hair growth along the wound margin was evaluated with wound breaking strength, wound closure rate, and quantitative histology.

RESULTS: CPA stimulated proliferation of BALB/3T3 fibroblasts and human dermal microvascular endothelial cells in both quiescent and nonquiescent phases. Wounds treated with CPA at 10 microM
showed a significant increase in the number of BrdU-labeled cells, including keratinocytes, fibroblasts, endothelial cells, and cells in sebaceous glands and the outer root sheath of hair follicles, compared with controls (P < 0.05). CPA application (5.1 microg/daily for 12 days) significantly increased the breaking strength of incisional wounds at day 24 postwound (P < 0.05). Excisional wound closure rate in the CPA-treated group (3.4 microg/daily for 15 days) was accelerated starting at day 10 postwound compared with controls (P < 0.01). Tissue sections from CPA-treated wounds showed a sevenfold increase in hair follicle number, compared with controls (P < 0.01). Enhanced hair growth along the wound margin was revealed in CPA-treated groups.

CONCLUSION: CPA stimulated proliferation of many cell types in vivo and in vitro and enhanced wound healing and hair growth. Therefore, CPA could be an interesting candidate for clinical application.

Copyright 1999 Academic Press.

PMID: 10527699

 

[Guest]

Virtually all Germans I know can speak almost perfect English. In some cases they can even speak better English than us :-S

I remember a conversation I had with a German a couple of weeks ago and he bought up the word 'polycentric'; everyone just looked at him afraid to ask what it meant

 

[Temples]

I need to learn Japanese so I can get into urabon. Any tips, linguists?

 

[Bismarck]

Red Rose -
thank you for posting the studies. The first one refers to adonsine which seems to be a lot weaker than pure adenosine.

Here'S the CPA data sheet:


Harmonized Tariff Code: 29349990900
CAS Number: 041552823


Identifiers

Synonyms CPA
Molecular Formula C15H21N5O4
Molecular Weight 335.36
CAS Number 41552-82-3
MDL number MFCD00036845

Enlarge
Description

Biochem/physiol Actions Selective A1adenosine receptor agonist.
Physical form hygroscopic solid

Properties

solubility
DMSO 23 mg/mL
0.1 N HCl 12 mg/mL
water 1.7 mg/mL
color off-white to light yellow
storage temp. 2-8°C

References

Literature Lohse, et al., 2-Chloro-N6-cyclopentyladenosine: A highly
selective agonist at A1adenosine receptors., Naunyn-Schmiedeberg's Arch.
Pharmacol. 337, 687-689 (1988)
Klotz, et al., 2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CPPA) - A high
affinity agonist radioligand for A1adenosine receptors.
Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 679-683 (1989)

 

[Old Baldy]

Bis: What have you heard/think of Adenosine? I ordered a couple of bottles and am going to make a topical out of it. Do the guys in Germany have any stories to tell yet?

Btw, Red Rose, thanks for the info.