How do horseshoe follicles react to androgens?

[cyberprimate]

How do horseshoe follicles of men with male pattern baldness react to androgens? Is their growth stimulated or the opposite?

 

[LooseItAll]

If I recall correctly there was a study that involved injecting androgens into the so called androgen resistant hair which caused them to miniaturize and die.

All hair on the scalp are not resistant do DHT. It's just that the horseshoe hair follices do not have as many androgen receptors and reductase activity I guess.

 

[cyberprimate]

So the reaction of these follicles to Androgens is also negative, as opposed to body hair, right?

 

[cyberprimate]

Alright, so scalp follicles have a different nature from body follicles. They don't react well to androgens. Do they actually need androgens at all ?

 

[Bryan]

Alright, so scalp follicles have a different nature from body follicles. They don't react well to androgens. Do they actually need androgens at all ?

Scalp hair follicles don't need androgens at all.

 

[freakout]

Am I imagining the paradox that was presented on this thread or did I miss the boat? Or are you guys just keeping quite about it?

 

[Bryan]

Am I imagining the paradox that was presented on this thread or did I miss the boat? Or are you guys just keeping quite about it?

Sigh.

Yes, you're imagining some "paradox" in this thread.

 

[freakout]

I see. Let's see if they imagined a paradox too. And then I'll ask you.

 

[armandein]

Alright, so scalp follicles have a different nature from body follicles. They don't react well to androgens. Do they actually need androgens at all ?

Scalp hair follicles don't need androgens at all.

As evident in children!

Have children an operative sebaceous gland? Have sebum in children's hair? If yes, then androgens are working in pilosebaceous unit

 

[Bryan]

Scalp hair follicles don't need androgens at all.

Have children an operative sebaceous gland? Have sebum in children's hair? If yes, then androgens are working in pilosebaceous unit

That doesn't have anything at all to do with whether or not scalp hair follicles need androgens; nevertheless, I'd still be interested to hear the details of the Sebutape experiment that you did with your children. You never did say very much about that!

 

[cyberprimate]

Have sebum in children's hair? If yes, then androgens are working in pilosebaceous unit

Do scalp follicles need sebum production?

 

[armandein]

Scalp hair follicles don't need androgens at all.

Have children an operative sebaceous gland? Have sebum in children's hair? If yes, then androgens are working in pilosebaceous unit

That doesn't have anything at all to do with whether or not scalp hair follicles need androgens; nevertheless, I'd still be interested to hear the details of the Sebutape experiment that you did with your children. You never did say very much about that!

You are right my friend Bryan, my test with sebutape in children have not a good preparation, despite of your good advice (thank you). It could be interesting repeat the test, but really I detected sebum production in two children of 4 and 5 yeasrs old. And only with sebutape strips, not a HPLC colum
Sebaceous gland need androgens to make sebum and sebum is neccesary to have a good hair, despite the ideas of Mr. Kligman.

 

[armandein]

Have sebum in children's hair? If yes, then androgens are working in pilosebaceous unit

Do scalp follicles need sebum production?

In my opinion Yes, at least in living persons, did you see a scalp hair without sebum? only in the mummies.

 

[Bryan]

You are right my friend Bryan, my test with sebutape in children have not a good preparation, despite of your good advice (thank you). It could be interesting repeat the test, but really I detected sebum production in two children of 4 and 5 yeasrs old. And only with sebutape strips, not a HPLC colum

I was hoping to see scans you made of the Sebutape test-strips in two different locations on your children: 1) their hairy scalps, and 2) their hair-free foreheads. That way, we could compare how much sebum was made at those two different locations. I've never said that children don't make any sebum at all, just that they don't make very much. If you do the test in the way I recommend, it could probably help settle that idea you've suggested in the past about how hair follicles can supposedly generate their own androgens.

Sebaceous gland need androgens to make sebum and sebum is neccesary to have a good hair, despite the ideas of Mr. Kligman.

You've never provided any scientific evidence that sebum is necessary to have good hair. I don't consider those studies you've cited in the past to be "scientific evidence" of that.

 

[armandein]

You are right my friend Bryan, my test with sebutape in children have not a good preparation, despite of your good advice (thank you). It could be interesting repeat the test, but really I detected sebum production in two children of 4 and 5 yeasrs old. And only with sebutape strips, not a HPLC colum

I was hoping to see scans you made of the Sebutape test-strips in two different locations on your children: 1) their hairy scalps, and 2) their hair-free foreheads. That way, we could compare how much sebum was made at those two different locations. I've never said that children don't make any sebum at all, just that they don't make very much. If you do the test in the way I recommend, it could probably help settle that idea you've suggested in the past about how hair follicles can supposedly generate their own androgens.

Sebaceous gland need androgens to make sebum and sebum is neccesary to have a good hair, despite the ideas of Mr. Kligman.

You've never provided any scientific evidence that sebum is necessary to have good hair. I don't consider those studies you've cited in the past to be "scientific evidence" of that.

Hi Bryan,

the test was in april of 2008. I'll seek the scaned sebutape. I did press the sebutapes on hairy scalp during 2 minutes,
I remember that the sebutape test in my just cleaned and shamponing hair was negative, but in a children with few years was positive.
More investigation is neccesary IMHO.

I've never provided any scientific evidence that sebum is necessary to have good hair, but Dr. Kligman also never provide it. I don't consider those studies you've cited in the past of pseudohemaprodites or CAIS persons. It is simple to find out if these persons have sebum in his hair.
OTOH, any father or mother have detected the sebum in hair scalp of his young childrens, years before puberty. BTW, I don't know if this fact is pointed out in any scientific study.

 

[armandein]

Conclusions: Anti 5alpha-reducatase after hair transplant for MPHL has additive effect on hair thickness and global improvement. As MPHL has progressive miniaturizing tendency and it is not reversible, hair transplant only effectiveness is not long lasting. Surgico-medical therapy is more reasonable therapeutic option for MPHL....



donor dominance? :whistle:

more form Korea
http://www.ncbi.nlm.nih.gov/pubmed/12269871

 

[Bryan]

the test was in april of 2008. I'll seek the scaned sebutape. I did press the sebutapes on hairy scalp during 2 minutes, I remember that the sebutape test in my just cleaned and shamponing hair was negative, but in a children with few years was positive. More investigation is neccesary IMHO.

Didn't you also do the Sebutape test on their foreheads?? It wouldn't be very helpful if you did it ONLY on their scalps!

 

[armandein]

yes, I did test also in foreheads, and the result was negative in all cases.

 

[Bryan]

So you're saying you got more sebum on the scalp than on the forehead?

 

[freakout]

What's this discussion all about? To determine whether children have sebum?