Half-life of Nizoral Ketoconazole 2% Shampoo

[Einstein]

I read this over and over and still can't understand it. What exactly is the half-life of nizoral 2% ketoconalzole shampoo? Can anyone confirm this?

If it's only a few hours as is my interpretation of the passage below, then why are most of the people using it 2 or 3 times weekly??

Ketoconazole Shampoo (Shampoo 2 %)

Ketoconazole plasma concentrations decline in a biphasic manner. Initial phase half-life is approximately 2 hours, and the terminal phase half-life is approximately 8 hours. The effect of renal or hepatic impairment on plasma concentrations and half-life is unclear. Ketoconazole is partially metabolized through oxidation, dealkylation, and aromatic hydroxylation. Most of the ketoconazole and its metabolites are excreted into the bile and then the feces. The rest is excreted in the urine. In a study involving fasting adults with normal renal function, about 57% of a 200 mg oral dose of ketoconazole was excreted in the feces within 4 days. Between 20 - 65% of the ketoconazole excreted in the feces was unchanged drug. Within 4 days, approximately 13% of the dose was excreted in the urine; approximately 2 - 4% of this portion was as unchanged ketoconazole.

http://rx-s.net/weblog/more/ketoconazole-nizoral/

 

[squeegee]

I put that pink syrup twice a day on my head, 7 days a week. Why 3-4 times a week? I use a good thickening conditioner.

Japan study on the cream.. way better results than the shampoo.

http://www.hairsite.com/hair-loss/forum ... nswer.html

 

[Einstein]

Dude, as hard as it may be to believe by some, if I don't use the keto shampoo for about 4 days, my hairs begin to kiss the air before collapsing to the earth. I shed!

I searched the net to the best of my ability and the only answr I come across is that topical keto shampoo has a half life of a few hours. That's why it doesn't make sense to me why most are using it like 3x per week. That's like using minoxidil on wednesday and sundays and then report to the forums of how miserably minoxidil has failed them.

Those pictures are super impressive. It's mind boggling why many aren't using it.

 

[Bryan]

I read this over and over and still can't understand it. What exactly is the half-life of nizoral 2% ketoconalzole shampoo?

What exactly do you mean by that?

 

[squeegee]

I read this over and over and still can't understand it. What exactly is the half-life of nizoral 2% ketoconalzole shampoo?

What exactly do you mean by that?

Bryan this is a term mainly used in the body building community.. The half-life of a given medication is how long it takes for the body to get rid of half of the dose.! Bryan! You own me a full case of proxipen bottles!! :laugh:

 

[Bryan]

Bryan this is a term mainly used in the body building community.. The half-life of a given medication is how long it takes for the body to get rid of half of the dose.!

I'm referring to the term as it's used in the medical community; for example, the time-rate at which the level of a drug in the bloodstream goes down as it's slowly reduced by binding to certain receptors, or being degraded by certain other chemicals, and then eliminated by the liver.

None of those things, though, seem to have anything to do with the poster's original question about the "half-life" of ketoconazole shampoo, (presumably) as it sits on top of the scalp. I'd be very curious to know exactly what he means by that. I hope he answers!

 

[Einstein]

Oh, did I use the wrong term or something? :laugh:

What I mean is how long is the ketoconazole still active in the scalp doing it's thing (it's magic, it's work, or being effective as an anti androgen)? How long before it leaves and another "application" (shampoo) of ketoconazole is required?

Hope that makes sense. Not to familiar with the scientific jargons.

 

[Einstein]

I'm referring to the term as it's used in the medical community; for example, the time-rate at which the level of a drug in the bloodstream goes down as it's slowly reduced by binding to certain receptors, or being degraded by certain other chemicals, and then eliminated by the liver.

I think that's a close description of what I meant. The "idea" of it, not the technical aspect of it.

For example, we can't use finasteride every other day because the day we don't use it the dht will be kicking our hairs @ss. 1mg of finasteride is only good for one day. it needs to be taken everyday.

 

[Einstein]

I read this over and over and still can't understand it. What exactly is the half-life of nizoral 2% ketoconalzole shampoo?

What exactly do you mean by that?

Bryan this is a term mainly used in the body building community.. The half-life of a given medication is how long it takes for the body to get rid of half of the dose.! Bryan! You own me a full case of proxipen bottles!! :laugh:

lol lol

 

[Bryan]

Oh, did I use the wrong term or something? :laugh:

What I mean is how long is the ketoconazole still active in the scalp doing it's thing (it's magic, it's work, or being effective as an anti androgen)? How long before it leaves and another "application" (shampoo) of ketoconazole is required?

A while back (maybe a month or so), I remember posting in another thread in this site something to the effect that I don't think it's a good thing to talk about the "half-life" of ketoconazole in a shampoo AT ALL, because of big difficulties in determining how to actually measure it, and what it actually _means_. I emphasize all that again! What do you think actually happens to the ketoconazole in a shampoo, when you use it? Is a certain percentage of it washed off, when you rinse your hair? What is that percentage? :dunno: What happens if you apply some styling product to your hair, after using the shampoo? :dunno: What happens if you simply SCRATCH YOUR HEAD, sometime after using the shampoo??

I don't know the answers to those questions, either, but it does seem kind of silly to talk about the "half-life" of ketoconazole in a shampoo, as if that means anything technical at all. I'd avoid using that cryptic expression altogether, and simply ask something more mundane like: "How often should I use ketoconazole shampoo? Twice a week? Three times a week?" That's about all you can hope for!

 

[Einstein]

Oh, did I use the wrong term or something? :laugh:

What I mean is how long is the ketoconazole still active in the scalp doing it's thing (it's magic, it's work, or being effective as an anti androgen)? How long before it leaves and another "application" (shampoo) of ketoconazole is required?

A while back (maybe a month or so), I remember posting in another thread in this site something to the effect that I don't think it's a good thing to talk about the "half-life" of ketoconazole in a shampoo AT ALL, because of big difficulties in determining how to actually measure it, and what it actually _means_. I emphasize all that again! What do you think actually happens to the ketoconazole in a shampoo, when you use it? Is a certain percentage of it washed off, when you rinse your hair? What is that percentage? :dunno: What happens if you apply some styling product to your hair, after using the shampoo? :dunno: What happens if you simply SCRATCH YOUR HEAD, sometime after using the shampoo??

I don't know the answers to those questions, either, but it does seem kind of silly to talk about the "half-life" of ketoconazole in a shampoo, as if that means anything technical at all. I'd avoid using that cryptic expression altogether, and simply ask something more mundane like: "How often should I use ketoconazole shampoo? Twice a week? Three times a week?" That's about all you can hope for!

Yes using the term half life obviously shouldn't be used in the context I used it in, good point. But asking how long it should be used or how often it should be used is redundant. It's a guessing game with most using it, or they use it based on the instructions of usage for controlling dandruff.

I was looking for some scientific data to comfirm why people use it 2x-3x per week for treating male pattern baldness when that frequency is only directed to those using it to control dandruff. I'm confident if those who use it every 3 days or so use it on a daily basis will see better results, because not using it for 2 days or so is leaving your androgens receptors to bind with andogenic hormones (did I say that right?). It's like using finasteride 1mg every 3rd day.