Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche

Armando Jose

Armando Jose

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pubmed.ncbi.nlm.nih.gov

Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche - PubMed

Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (T<sub>reg</sub> cells) are emerging as a critical component of the stem-cell niche for supporting their differentiation. How T<sub>reg</sub> cells...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
A recent paper regarding complex hair biology
Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a critical component of the stem-cell niche for supporting their differentiation. How Treg cells sense dynamic signals in this microenvironment and communicate with stem cells is mostly unknown. In the present study, by using hair follicles (HFs) to study Treg cell-stem cell crosstalk, we show an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Treg cells to facilitate HF stem-cell (HFSC) activation and HF regeneration. Ablation of the glucocorticoid receptor (GR) in Treg cells blocks hair regeneration without affecting immune homeostasis. Mechanistically, GR and Foxp3 cooperate in Treg cells to induce transforming growth factor β3 (TGF-β3), which activates Smad2/3 in HFSCs and facilitates HFSC proliferation. The present study identifies crosstalk between Treg cells and HFSCs mediated by the GR-TGF-β3 axis, highlighting a possible means of manipulating Treg cells to support tissue regeneration.
 
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notoriousone

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Armando Jose said:
pubmed.ncbi.nlm.nih.gov

Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche - PubMed

Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (T<sub>reg</sub> cells) are emerging as a critical component of the stem-cell niche for supporting their differentiation. How T<sub>reg</sub> cells...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
A recent paper regarding complex hair biology
Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a critical component of the stem-cell niche for supporting their differentiation. How Treg cells sense dynamic signals in this microenvironment and communicate with stem cells is mostly unknown. In the present study, by using hair follicles (HFs) to study Treg cell-stem cell crosstalk, we show an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Treg cells to facilitate HF stem-cell (HFSC) activation and HF regeneration. Ablation of the glucocorticoid receptor (GR) in Treg cells blocks hair regeneration without affecting immune homeostasis. Mechanistically, GR and Foxp3 cooperate in Treg cells to induce transforming growth factor β3 (TGF-β3), which activates Smad2/3 in HFSCs and facilitates HFSC proliferation. The present study identifies crosstalk between Treg cells and HFSCs mediated by the GR-TGF-β3 axis, highlighting a possible means of manipulating Treg cells to support tissue regeneration.
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Random but do you think Flonase which contains glucocorticoid can have an effect on hair loss? @pegasus2/@Armando Jose any thoughts?
 
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RagnarLothbrok

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Microinflammation is known to accelerate and worsen Androgenetic Alopecia, yet corticoids that block and treat inflammation don't seem to help much.
 
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RagnarLothbrok

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Capone said:
pubmed.ncbi.nlm.nih.gov

Glucocorticoid effect on hair growth initiation: a reconsideration - PubMed

It has been demonstrated by various workers in the past that glucocorticosteroids block hair growth. Using the mouse model for studying hair growth induction we reexamined the effect of topically applied steroids on hair growth to establish at what stage the steroid block acts. In accord with...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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These studies and those of others lead us to conclude that these steroids block the expression of hair-forming genes, but do not interfere with the signal(s) that initiates those genes. This system appears to be ideal for identifying the signals (perhaps, genes) responsible for initiating hair growth.

Ok, that explains a lot... pretty weird it acts that way lol
 
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