Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

[Squeegee 2.0]

Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia.​

Androgenetic alopecia (Androgenetic Alopecia), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the phenotype. We demonstrate that genetic variability in the androgen receptor gene (AR) is the cardinal prerequisite for the development of early-onset Androgenetic Alopecia, with an etiological fraction of 0.46. The investigation of a large number of genetic variants covering the AR locus suggests that a polyglycine-encoding GGN repeat in exon 1 is a plausible candidate for conferring the functional effect. The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of Androgenetic Alopecia

Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

Androgenetic alopecia (Androgenetic Alopecia), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predi…

www.sciencedirect.com

 

[Moz5x]

Nice post, interesting stuff.


“…Our genetic data, however, stress the relative importance of the maternal line in the inheritance of Androgenetic Alopecia, since we estimate an etiological fraction of 0.46 that can be attributed to having ≤23 GGN repeats within AR. This suggests that the average phenotypic resemblance should be greater between affected males and their maternal grandfathers than between affected males and their fathers.”

 

[Mr. Slap Head]

No kidding lol

 

[Frenchboy]

My maternal grandfather : NW1 until 80yo
Me : NW3 at 22yo

f***, unlucky till the end lol. At least, my father and uncles went bald super slowly even if they start young, they're all NW5A/6A, vertex almost perfect.

 

[Moz5x]

Key words…”should” and “suggests”. LOL.