Finasteride vs saw palmetto.

[sam-]

Finasteride:
-Finasteride produces a rapid reduction in serum DHT concentration, reaching 65% suppression within 24 hours of oral dosing with a 1-mg tablet.(3)
-PROPECIA * (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5(alpha)-reductase. (3)
-Type I 5(alpha)-reductase is responsible for approximately one-third of circulating DHT. The Type II 5(alpha)-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT. (3)



saw palmetto:
-the saw palmetto supplement led to a 32% decrease in DHT levels.(1)
-saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone. Those in the finasteride group had a 70% decrease in blood levels of the hormone. (1)
-As a matter of fact, Saw Palmetto is an inhibitor stronger than finasteride in vitro: for type II, the inhibiting concentration of finasteride is 7.3nM and that of Saw Palmetto is 7.2μg/ml. For type I, finasteride is considered inefficient with an inhibiting in vitro concentration of 108nM and Saw Palmetto is efficient with a 4.9μg/ml concentration. (2)
-The Saw Palmetto lipid extract is a noncompetitive inhibitor of type I 5-α-reductase isozymes and incompetitive type II. (2)




References:
(1) http://www.emersonecologics.com/Newswire.asp?id=3
(2) http://www.magistralbiotech.com/docs/sc ... almcia.pdf
(3) http://www.drugs.com/PDR/Propecia_Tablets.html



Folks, if you find something else please add it to those tables.

 

[Melbs]

Interesting... I have been tossing up between both for a while. I stopped Proscar for about 2 months, a result of slackness after 3 years of use, then started on Saw Palmetto for about 1 month, now im taking both. Hopefully its not a lethal combination or one which will create larger problems, but i think im gonna give it a go for 3 months... see what happens. I have also stopped applying Minoxidil after 6 weeks of frustrating, very stressful and annoying times.

 

[dead]

Interesting... I have been tossing up between both for a while. I stopped Proscar for about 2 months, a result of slackness after 3 years of use, then started on Saw Palmetto for about 1 month, now im taking both. Hopefully its not a lethal combination or one which will create larger problems, but i think im gonna give it a go for 3 months... see what happens. I have also stopped applying Minoxidil after 6 weeks of frustrating, very stressful and annoying times.

Melbs did you read the post above ?

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

 

[Gus]

Proscar + Saw Palmetto right here as well. Don't know if it will help but willing to give anything a try.

 

[dead]

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

saw palmetto’s effects on DHT were centered only in the prostate and did not affect blood levels of the hormone.

 

[Bismarck]

nice Tynan,
but wrong.

 

[dead]

nice Tynan,
but wrong.

The study was wrong ?

 

[Bismarck]

nice Tynan,
but wrong.

The study was wrong ?

It's not only in the prostate but also in skin and other tissues.

 

[dead]

nice Tynan,
but wrong.

The study was wrong ?

It's not only in the prostate but also in skin and other tissues.

I read it as 'centered' (read as 'mainly') in the prostate, the important thing is that blood DHT levels were not significantly lowered.

 

[juststarting]

Yawn, this place is so funny. The same questions rehashed again and again and again and again. Seriously, how do you admins deal with all the lazy f*ckheads who can't be bothered with a simple forum search???

Yes, this has been dealt with and is even on the web site of this forum.

 

[dead]

Yes, this has been dealt with and is even on the web site of this web site.

This web site has got a web site ? Where is this web site on a web site, is it itself on some kind of web site ?

 

[juststarting]

Lol, my mistake. This FORUM's web site

 

[sam-]

>>>the enzyme form present in a larger concentration in the scalp is the type I 5-α-
Reductase<<<
wouldn’t saw palmetto be more effective than finasteride in that area !!! (after all we want it to treat the hair scalp not the prostate or the blood....)

any thoughts……….. :roll:

 

[sam-]

I think I understood now the whole subject about “saw palmettoâ€￾, thanks “mvpsoftâ€￾:

mvpsoft wrote:
1. To combat hair loss, propecia lowers the amount of DHT in the blood, which in turn lowers the amount of DHT in the scalp. It's lowering DHT in the scalp that's critical for hair loss. Propecia in sufficient dosages will also lower DHT in the prostate. However, saw palmetto taken orally apparently lowers DHT in the prostate but has no effect on scalp DHT at all. Thus, merely lowering DHT is not sufficient -- it's scalp DHT that is at issue for hair loss, and saw palmetto taken orally is competely useless in lowering scalp DHT.

2. It's possible that saw palmetto applied topically might have some effect on lowering scalp DHT, but whether it does is unkown. Since it doesn't cause scalp irritation and is cheap, there is no harm in including it in topical products. However, since so many people (erroneously) believe the saw palmetto is general a "DHT fighter," the biggest reason for including it in topical preparations is a marketing one. That doesn't mean it does squat, it means only that it helps sell the product. There is nothing unethical about this since saw palmetto doesn't hurt anything.

http://www.hairlosstalk.com/discussions ... hp?t=12224

:2gunsfiring_v1: Goodbye oral saw palmetto.

 

[MiddleAgedManiac]

Beta-Sis

So, since Beta-Sitosterol is the active ingredient in SP, it's safe to say it's crap as well. I can say that I have used both and my hairloss has not slowed for the two years I have taken them.

 

[Old Baldy]

Guys, when you get older prostate health is important. SP and Beta Sis can help keep your prostate healthy.

The jury's out on topical SP but a small study (that was shown to be not very reliable by the veterans) did show positive effect. It's cheap and easy to add to your homemade concoctions.

 

[dead]

Guys, when you get older prostate health is important. SP and Beta Sis can help keep your prostate healthy.

The jury's out on topical SP but a small study (that was shown to be not very reliable by the veterans) did show positive effect. It's cheap and easy to add to your homemade concoctions.

Also anecdotal evidence show that people taking SP tend to go through extended periods of shedding.

 

[Old Baldy]

I haven't Ty but I've been taking SP for years. Maybe I've been shedding all that time?! :lol: :lol: :shock:

 

[dead]

I haven't Ty but I've been taking SP for years. Maybe I've been shedding all that time?! :lol: :lol: :shock:

maybe :freaked2: !!!!!!

HairLossTalk.com himself wrote a long thread on the subject of extended sheds on SawP, pretty much everyone (in that thread) he asked who was taking SawP reported little benefit accompanied by prolonged sheds.

 

[Shinyscalp23]

saw palmetto

wouldnt it make sense, however, that by lowering the dht in your prostate after an extended period of time, you, by default, reduce overall dht levels in your blood, in turn, lowering dht levels on your scalp?