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Actas Dermosifiliogr. 2010 Apr;101(3):248-56
[Male androgenetic alopecia and cardiovascular risk factors: A
case-control study]
[Article in Spanish]
Arias-Santiago S, Gutierrez-Salmeron MT, Castellote-Caballero L,
Buendia-Eisman A, Naranjo-Sintes R.
Servicio de Dermatologia, Hospital Clinico San Cecilio, Granada, Espana.
BACKGROUND AND OBJECTIVES: The relationship between androgenetic
alopecia and cardiovascular disease has been studied by some authors in
the past, although the results of epidemiological studies have been
variable. The objective of this study was to determine the prevalence of
metabolic syndrome and carotid arteriosclerosis in patients with
early-onset androgenetic alopecia. PATIENTS AND METHODS: Seventy men
were studied, 35 with diagnosis of early-onset (before 35 years of age)
androgenetic alopecia and 35 control subjects who consulted for other
skin conditions. In both groups, the criteria for metabolic syndrome
according to the Adult Treatment Panel-III were studied (obesity,
triglycerides, high-density lipoprotein cholesterol, systolic and
diastolic blood pressure, and blood glucose), presence of atheromatous
plaques, and carotid intima-media thickness using Doppler
ultrasonography. Other cardiovascular risk factors, hormones, and
acute-phase reactants were also analyzed. RESULTS: Criteria for
metabolic syndrome were met by 57.1% of the patients with androgenetic
alopecia compared to 14.3% of the controls (P<0001). Thirty-four percent
of the patients with androgenetic alopecia had atheromatous plaques
compared to 8.6% of the controls (P=.018). In an independent correlation
analysis, abdominal obesity, systolic blood pressure, triglycerides, and
blood glucose levels were significantly greater among patients with
androgenetic alopecia. Testosterone and sex hormone binding globulin
levels were similar in the 2 groups whereas insulin and aldosterone
levels were higher in patients with androgenetic alopecia (P<05).
CONCLUSIONS: The high frequency of metabolic syndrome and carotid
atheromatous plaques in patients with androgenetic alopecia suggests
cardiovascular screening should be done to enable early detection of
individuals at risk and initiation of preventive treatment before
cardiovascular disease becomes established.
Publication Types:
* English Abstract
PMID: 20398601
[Male androgenetic alopecia and cardiovascular risk factors: A
case-control study]
[Article in Spanish]
Arias-Santiago S, Gutierrez-Salmeron MT, Castellote-Caballero L,
Buendia-Eisman A, Naranjo-Sintes R.
Servicio de Dermatologia, Hospital Clinico San Cecilio, Granada, Espana.
BACKGROUND AND OBJECTIVES: The relationship between androgenetic
alopecia and cardiovascular disease has been studied by some authors in
the past, although the results of epidemiological studies have been
variable. The objective of this study was to determine the prevalence of
metabolic syndrome and carotid arteriosclerosis in patients with
early-onset androgenetic alopecia. PATIENTS AND METHODS: Seventy men
were studied, 35 with diagnosis of early-onset (before 35 years of age)
androgenetic alopecia and 35 control subjects who consulted for other
skin conditions. In both groups, the criteria for metabolic syndrome
according to the Adult Treatment Panel-III were studied (obesity,
triglycerides, high-density lipoprotein cholesterol, systolic and
diastolic blood pressure, and blood glucose), presence of atheromatous
plaques, and carotid intima-media thickness using Doppler
ultrasonography. Other cardiovascular risk factors, hormones, and
acute-phase reactants were also analyzed. RESULTS: Criteria for
metabolic syndrome were met by 57.1% of the patients with androgenetic
alopecia compared to 14.3% of the controls (P<0001). Thirty-four percent
of the patients with androgenetic alopecia had atheromatous plaques
compared to 8.6% of the controls (P=.018). In an independent correlation
analysis, abdominal obesity, systolic blood pressure, triglycerides, and
blood glucose levels were significantly greater among patients with
androgenetic alopecia. Testosterone and sex hormone binding globulin
levels were similar in the 2 groups whereas insulin and aldosterone
levels were higher in patients with androgenetic alopecia (P<05).
CONCLUSIONS: The high frequency of metabolic syndrome and carotid
atheromatous plaques in patients with androgenetic alopecia suggests
cardiovascular screening should be done to enable early detection of
individuals at risk and initiation of preventive treatment before
cardiovascular disease becomes established.
Publication Types:
* English Abstract
PMID: 20398601